Flavones from Coleus amboinicus

Article (PDF Available)inPhilippine Journal of Science 128(4):347-351 · January 1999with 340 Reads
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Abstract
The air-dried leaves of Coleus amboinicus Lour. afforded three flavones: salvigenin, cirsimaritin and chrysoeriol by silica gel chromatography. Their structures were elucidated by 1D and 2D NMR and UV spectroscopy. Antimicrobial assay on salvigenin and cirsimaritin indicated that they have low antimicrobial activities against P. aeruginosa, B. subtilis, E. coli, S. aureus, C. albicans, T. mentagrophytes and a. niger.
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    The shade-dried powder of leaves of Plectranthus amboinicus (Lour) Spreng was subjected to successive extraction using the various solvents (petroleum ether, chloroform, ethanol and water) in increasing order of polarity. The preliminary phytochemical analyses were carried out for all the extracts. The analyses of the leaves revealed the presence of alkaloids, carbohydrates, glycosides, proteins, amino acids, flavonoids, quinine, tannins, phenolic compounds and terpenoids. Since the phytoconstituents present in the ethanolic and aqueous extracts were similar, both the extracts were selected for further study. The diuretic properties of ethanolic and aqueous extracts were evaluated by determination of urine volume and electrolyte concentration in male albino rats. Furosemide (10 mg/kg) was used as standard while normal saline (0.9%) was used as control. Both ethanolic and aqueous extracts (500 mg/kg) have shown significant increase in the volume of urine and urinary concentration of Na, K and Cl ions. Thus, from the is study it may be concluded that the leaves of P. amboinicus (Lour) Spreng possess diuretic activities.
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    The shade-dried powder of leaves of Plectranthus amboinicus (Lour) Spreng was subjected to successive extraction using the solvents, pet. ether, chloroform, ethanol and water, in the increasing order of polarity. A preliminary phytochemical analysis was carried out for all the extracts. It was found that the leaves revealed the presence of alkaloids, carbohydrates, glycosides, proteins, amino acids, fl avonoids, quinine, tannins, phenolic compounds and terpenoids. Because the phytoconstituents present in the ethanolic and aqueous extracts were similar, both extracts were selected for further study. The hepatoprotective effects of ethanolic and aqueous extracts were evaluated against carbon tetrachloride (CCl 4)-induced hepatotoxicity on Wistar albino rats. CCl 4 signifi cantly (P < 0.01) elevated the serum level of biochemical parameters such as aspartate transaminase, alanine transaminase, alkaline phosphate, gamma-glutamyl transpeptidase and bilirubin (total and direct). Rats treated with the ethanolic extract showed a prominent restoration (P < 0.01) whereas the aqueous extract showed a mild restoration (P < 0.01) of all the parameters. The ethanolic and aqueous extract-treated groups also showed regeneration of hepatocytes, normalization of fatty changes and necrosis. Thus, from the present study, it may concluded that the leaves of Plectranthus amboinicus (Lour) Spreng posses hepatoprotective activities to support its traditional uses.
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    The leaves of Plectranthus amboinicus (Lour) Spreng were traditionally used for the treatment of pyrexia and acute pains. The present study was carried out using acetic acid-induced writhing and tail immersion tests in mice while, yeast-induced pyrexia in rats. The leaves were subjected to successive extraction using the various solvents (petroleum ether, chloroform, ethanol and water) in the increasing order of polarity. It was found that the leaves revealed the presence of alkaloids, carbohydrates, glycosides, proteins, amino acids, flavonoids, quinine, tannins, phenolic compounds and terpenoids. Both extracts (500 mg/kg, p.o.) produced the significant (P<0.01) Antinociceptive and antipyretic effects. The observed pharmacological activities provide the scientific basis to support traditional claims as well as, exploring some new and promising leads. INTRODUCTION Analgesia (pain) is an ill defined unpleasant, sensation usually evoked by an external or internal noxious stimulus. Pain is a warning signal and primarily protective in nature, but causes discomfort. Analgesics are the drug that selectively relieves pain by acting in the CNS or on peripheral pain mechanisms, without significantly altering consciousness. The plant Plectranthus amboinicus (Lour.) Spreng belongs to family Lamiaceae, known as country borage in English. 1 It is large succulent aromatic perennial herb, shrubby below, hispidly villous or tomentose. 2 It is found or cultivated
  • Article
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    Plectranthus amboinicus (Lour) Spreng belongs to family Lamiaceae, known as country borage in English. It is large succulent aromatic perennial herb, shrubby below, hispidly villous or tomentose. It is found throughout India, Ceylon and Moluccas. The leaves of the plant are bitter, acrid and were being widely used traditionally for various purposes. The plant has been worked out very well and isolated several chemical constituents and had shown various biological properties. This review is an effort to compile all the information reported on its phytochemical and pharmacological activities. The present review is an attempt to generate interest among the masses regarding its immense potential in preventing and treating the several diseases.
  • Article
    Full-text available
    Plectranthus amboinicus (Lour) Spreng belongs to family Lamiaceae and known as country borage in English. It is large succulent aromatic perennial herb, shrubby below, hispidly villous or tomentose. It is found throughout India, Sri Lanka and Moluccas. The leaves of the plant are bitter, acrid and were being widely used traditionally for various purposes. The present study was therefore carried out to provide requisite pharmacognostic details about the leaf. The leaf was characterized for its physico-chemical properties. The shade dried powder of leaves of Plectranthus amboinicus (Lour) Spreng was subjected to successive extraction using the solvents (petroleum ether, chloroform, ethanol and water) in the increasing order of polarity. The preliminary phytochemical analysis and Thin Layer Chromatography has been performed. It was found that the leaves revealed the presence of alkaloids, carbohydrates, glycosides, proteins, amino acids, flavonoids, quinone, tannins, phenolic compounds and terpenoids. The findings will be useful towards establishing pharmacognostic standards for identification, purity, quality and preparation of monograph of the plant.
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