Effect of antioxidants L-ascorbic acid and alpha-tocopherol supplementation in nickel exposed hyperglycemic rats

Environmental Health Research Unit, Department of Physiology, Al-Ameen Medical College, Bijapur 586108, Karnataka, India.
Journal of basic and clinical physiology and pharmacology 02/2008; 19(2):89-101. DOI: 10.1515/JBCPP.2008.19.2.89
Source: PubMed


Nickel-induced hyperglycemia in rats under both acute and subchronic exposure conditions could be due to increased hepatic glycogenolysis, increased pancreatic release of glucagon, decreased peripheral utilization of glucose, or gluconeogenesis. We studied the effect of acute and subchronic nickel sulfate treatment on Wister strain male albino rats simultaneously treated with combined L-ascorbic acid and alpha-tocopherol. The simultaneous treatment with L-ascorbic acid or alpha-tocopherol appears to be beneficial for regulating glucose homeostasis in rats. A significant rise of blood glucose level was also observed with L-ascorbic acid supplementation alone, but not in the case of alpha-tocopherol supplementation alone.

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Available from: Kusal K. Das, Apr 02, 2014
    • "Previous human and experimental studies on metal exposure have reported nickel and arsenic exposure to be associated with diabetes risk[6,2728. Several studies have suggested that nickel might damage insulin function, induce hyperglycemia, increase hepatic glycolysis and pancreatic glucagon release, decrease peripheral utilization of glucose, induce gluconeogenesis, and increase plasma glucose levels10112930. Similar findings for diabetes risk have been shown in the art glass industry and in copper smelter workers[6,14,3132. Copper, the third-most abundant essential transition metal in the human body, may play an important role in the pathogenesis of diabetes, including the induction of pancreatic islet cell degeneration and facilitation of hydrogen peroxide generation from amylin[33]. "
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