A look inside the diabetic brain: Contributors to diabetes-induced brain aging

Department of Pharmacology, Physiology and Neuroscience University of South Carolina, School of Medicine, Columbia, SC 29208, USA.
Biochimica et Biophysica Acta (Impact Factor: 4.66). 12/2008; 1792(5):444-53. DOI: 10.1016/j.bbadis.2008.10.013
Source: PubMed


Central nervous system (CNS) complications resulting from diabetes is a problem that is gaining more acceptance and attention. Recent evidence suggests morphological, electrophysiological and cognitive changes, often observed in the hippocampus, in diabetic individuals. Many of the CNS changes observed in diabetic patients and animal models of diabetes are reminiscent of the changes seen in normal aging. The central commonalities between diabetes-induced and age-related CNS changes have led to the theory of advanced brain aging in diabetic patients. This review summarizes the findings of the literature as they relate to the relationship between diabetes and dementia and discusses some of the potential contributors to diabetes-induced CNS impairments.

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    • "The prevalence of diabetes in Egypt was 3.9% in 2000 and is expected to rise to 6.8% by the year 2030 which would make Egypt one of the highest 10 countries with diabetes in 2030 [2]. Diabetes often results in microvascular and macrovascular complications such as retinopathy, peripheral neuropathy, stroke, and coronary heart disease [1]. Hypertension is very frequently associated with diabetic subjects, irrespective of whether they are type 1 or type 2 [3]. "
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