Reduced serotonergic functioning changes heart rate in ADHD

ArticleinJournal of Neural Transmission 116(1):105-8 · December 2008with4 Reads
Impact Factor: 2.40 · DOI: 10.1007/s00702-008-0146-0 · Source: PubMed


    Reduced mean heart rate (HR) was shown to be a biophysiological marker for aggression, which in turn was proven to be related to changed serotonergic neurotransmission. A total of 16 ADHD-diagnosed boys were subjected to rapid tryptophan depletion (RTD) and a placebo in a double-blind within-subject crossover-design. Mean HR was assessed under RTD/placebo. Low impulsive patients behaving aggressively under RTD showed a lowered HR under RTD versus placebo. Diminished 5-HT functioning was associated with lowered HR and aggressive behaviour.