Article

AutDB: A gene reference resource for autism research

MindSpec Inc., 9656 Blake Lane, Fairfax, VA 22031, USA.
Nucleic Acids Research (Impact Factor: 9.11). 12/2008; 37(Database issue):D832-6. DOI: 10.1093/nar/gkn835
Source: PubMed

ABSTRACT

Recent advances in studies of Autism Spectrum Disorders (ASD) has uncovered many new candidate genes and continues to do so
at an accelerated pace. To address the genetic complexity of ASD, we have developed AutDB (http://www.mindspec.org/autdb.html), a publicly available web-portal for on-going collection, manual annotation and visualization of genes linked to the disorder.
We present a disease-driven database model in AutDB where all genes connected to ASD are collected and classified according
to their genetic variation: candidates identified from genetic association studies, rare single gene mutations and genes linked
to syndromic autism. Gene entries are richly annotated for their relevance to autism, along with an in-depth view of their
molecular functions. The content of AutDB originates entirely from the published scientific literature and is organized to
optimize its use by the research community. The main focus of this resource is to provide an up-to-date, annotated list of
ASD candidate genes in the form of reference dataset for interrogating molecular mechanisms underlying the disorder. Our model
for consolidated knowledge representation in genetically complex disorders could be replicated to study other such disorders.

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Available from: Sharmila Banerjee-Basu
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