Folic acid The right dose

Canadian family physician Medecin de famille canadien (Impact Factor: 1.34). 12/2008; 54(11):1545-7.
Source: PubMed


ABSTRACTQUESTION The new Motherisk Guidelines suggest 5 mg/d of folic acid. Why was the dose increased? What is the time frame for taking such a dose?ANSWER Recent data from Ontario reveal that 40% of women of reproductive age still do not achieve therapeutic systemic levels of folate needed to prevent neural tube defects. Compliance is less than optimal among women using prenatal vitamins, rendering many women unprotected against neural tube defects. Taking a higher dose of folate will allow achievement of protective folate levels, even with partial compliance. Five mg of folate should be used daily several months before conception until the end of the first trimester.

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Available from: Y. Ingrid Goh, May 16, 2014
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    • "Interestingly, Canada’s Motherisk program based in the Hospital for Sick Children, Ontario, recently changed its folic acid guidelines to 5mg/d for all women. This was after a recent study determined that 40% of Ontario women were not achieving optimally protective levels, despite fortification and supplementation [24]. Additionally, the 2007 guidelines from the Motherisk program and the Society of Obstetricians and Gynecologists of Canada call for 5mg/d for women with a variety of medical and social indications, including minority status, epilepsy, obesity, substance abuse, poor medication compliance, and lack of birth control [25]. "
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