Spectacle lens compensation in the pigmented guinea pig

School of Psychology, Faculty of Science and Information Technology, The University of Newcastle, Australia.
Vision research (Impact Factor: 1.82). 12/2008; 49(2):219-27. DOI: 10.1016/j.visres.2008.10.008
Source: PubMed


When a young growing eye wears a negative or positive spectacle lens, the eye compensates for the imposed defocus by accelerating or slowing its elongation rate so that the eye becomes emmetropic with the lens in place. Such spectacle lens compensation has been shown in chicks, tree-shrews, marmosets and rhesus monkeys. We have developed a model of emmetropisation using the guinea pig in order to establish a rapid and easy mammalian model. Guinea pigs were raised with a +4D, +2D, 0D (plano), -2D or -4D lens worn in front of one eye for 10 days or a +4D on one eye and a 0D on the fellow eye for 5 days or no lens on either eye (littermate controls). Refractive error and ocular distances were measured at the end of these periods. The difference in refractive error between the eyes was linearly related to the lens-power worn. A significant compensatory response to a +4D lens occurred after only 5 days and near full compensation occurred after 10 days when the effective imposed refractive error was between 0D and 8D of hyperopia. Eyes wearing plano lenses were slightly more myopic than their fellow eyes (-1.7D) but showed no difference in ocular length. Relative to the plano group, plus and minus lenses induced relative hyperopic or myopic differences between the two eyes, inhibited or accelerated their ocular growth, and expanded or decreased the relative thickness of the choroid, respectively. In individual animals, the difference between the eyes in vitreous chamber depth and choroid thickness reached +/-100 and +/-40microm, respectively, and was significantly correlated with the induced refractive differences. Although eyes responded differentially to plus and minus lenses, the plus lenses generally corrected the hyperopia present in these young animals. The effective refractive error induced by the lenses ranged between -2D of myopic defocus to +10D of hyperopic defocus with the lens in place, and compensation was highly linear between 0D and 8D of effective hyperopic defocus, beyond which the compensation was reduced. We conclude that in the guinea pig, ocular growth and refractive error are visually regulated in a bidirectional manner to plus and minus lenses, but that the eye responds in a graded manner to imposed effective hyperopic defocus.

Full-text preview

Available from:
  • Source
    • "In contrast, Schaeffel et al. (Schaeffel et al., 1988) demonstrated through the use of positive and negative lenses of specific refractive powers that chicks could accurately compensate for imposed myopic or hyperopic defocus by modulating the axial length of the eye. Lens compensation was subsequently demonstrated in tree shrews (Norton et al., 2010), monkeys (Smith et al., 2010), guinea pigs (Howlett and McFadden, 2009), and mice (Tkatchenko et al., 2010). Remarkably, studies using animal models have demonstrated that young eyes can recover from induced myopia following removal of the diffuser or negative lens (Siegwart and Norton, 1998; Wallman and Adams, 1987). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Myopia is a common ocular condition, characterized by excessive elongation of the ocular globe. The prevalence of myopia continues to increase, particularly among highly educated groups, now exceeding 80% in some groups. In parallel with the increased prevalence of myopia, are increases in associated blinding ocular conditions including glaucoma, retinal detachment and macular degeneration, making myopia a significant global health concern. The elongation of the eye is closely related to the biomechanical properties of the sclera, which in turn are largely dependent on the composition of the scleral extracellular matrix. Therefore an understanding of the cellular and extracellular events involved in the regulation of scleral growth and remodeling during childhood and young adulthood will provide future avenues for the treatment of myopia and its associated ocular complications. Copyright © 2014 Elsevier Ltd. All rights reserved.
    Full-text · Article · Apr 2015 · Experimental Eye Research
  • Source
    • "Several lines of evidence indicate that ocular growth and refractive development in a wide range of animal species are regulated by visual feedback associated with the eye's refractive state (Smith, 2011; Wallman & Winawer, 2004). The most direct evidence comes from lens-compensation experiments that have shown that optically imposed changes in the eye's effective refractive state produce predictable changes in ocular growth and refractive development (Howlett & McFadden, 2009; Hung, Crawford, & Smith, 1995; Schaeffel, Glasser, & Howland, 1988; Schaeffel & Howland, 1991; Shaikh, Siegwart, & Norton, 1999; Smith & Hung, 1999; Whatham & Judge, 2001). For instance, in response to relative hyperopic defocus optically imposed via negative-powered lenses, the eyes of developing animals consistently elongate and develop degrees of myopia that compensate for the induced optical error. "
    [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to investigate the changes in ocular shape and relative peripheral refraction during the recovery from myopia produced by form deprivation (FD) and hyperopic defocus. FD was imposed in six monkeys by securing a diffuser lens over one eye; hyperopic defocus was produced in another six monkeys by fitting one eye with -3D spectacle. When unrestricted vision was re-established, the treated eyes recovered from the vision-induced central and peripheral refractive errors. The recovery of peripheral refractive errors was associated with corresponding changes in the shape of the posterior globe. The results suggest that vision can actively regulate ocular shape and the development of central and peripheral refractions in infant primates.
    Preview · Article · Sep 2012 · Vision research
  • Source
    • "Previous studies with chickens have also reported a significant disruption of the natural diurnal rhythms in choroidal thickness in eyes exposed to myopic defocus, with choroidal rhythms found to be significantly phase advanced (Nickla et al., 1998; Nickla, 2006; Papastergiou et al., 1998). Choroidal thickening, associated with periods of myopic defocus has also been widely noted in avians (Nickla et al., 2005; Park et al., 2003; Wallman et al., 1995; Wildsoet and Wallman, 1995; Zhu et al., 2003), mammals (Howlett and McFadden, 2009), and primates (Hung et al., 2000; Troilo et al., 2000). Previous studies of daily rhythms of choroidal thickness in human eyes have only examined subfoveal measures (Brown et al., 2009; Chakraborty et al., 2011). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Recent research indicates that brief periods (60 min) of monocular defocus lead to small but significant changes in human axial length. However, the effects of longer periods of defocus on the axial length of human eyes are unknown. We examined the influence of a 12 h period of monocular myopic defocus on the natural daily variations occurring in axial length and choroidal thickness of young adult emmetropes. A series of axial length and choroidal thickness measurements (collected at ∼3 hourly intervals, with the first measurement at ∼9 am and the final measurement at ∼9 pm) were obtained for 13 emmetropic young adults over three consecutive days. The natural daily rhythms (Day 1, baseline day, no defocus), the daily rhythms with monocular myopic defocus (Day 2, defocus day, +1.50 DS spectacle lens over the right eye), and the recovery from any defocus induced changes (Day 3, recovery day, no defocus) were all examined. Significant variations over the course of the day were observed in both axial length and choroidal thickness on each of the three measurement days (p < 0.0001). The magnitude and timing of the daily variations in axial length and choroidal thickness were significantly altered with the monocular myopic defocus on day 2 (p < 0.0001). Following the introduction of monocular myopic defocus, the daily peak in axial length occurred approximately 6 h later, and the peak in choroidal thickness approximately 8.5 h earlier in the day compared to days 1 and 3 (with no defocus). The mean amplitude (peak to trough) of change in axial length (0.030 ± 0.012 on day 1, 0.020 ± 0.010 on day 2 and 0.033 ± 0.012 mm on day 3) and choroidal thickness (0.030 ± 0.007 on day 1, 0.022 ± 0.006 on day 2 and 0.027 ± 0.009 mm on day 3) were also significantly different between the three days (both p < 0.05). The introduction of monocular myopic defocus disrupts the daily variations in axial length and choroidal thickness of human eyes (in terms of both amplitude and timing) that return to normal the following day after removal of the defocus.
    Full-text · Article · Aug 2012 · Experimental Eye Research
Show more