Clinical Potential of Minocycline for Schizophrenia

Department of Psychiatry, Shimane University School of Medicine, Izumo, Japan.
CNS & neurological disorders drug targets (Impact Factor: 2.63). 11/2008; 7(4):376-81. DOI: 10.2174/187152708786441858
Source: PubMed


Minocycline, an antibiotic of the tetracycline family, has been shown to display neurorestorative or neuroprotective properties in various models of neurodegenerative diseases. In particular, it has been shown to delay motor alterations, inflammation and apoptosis in models of Huntington's disease, amyotrophic lateral sclerosis and Parkinson's disease. Despite controversies about its efficacy, the relative safety and tolerability of minocycline have led to various clinical trials. Recently, we reported the antipsychotic effects of minocycline in patients with schizophrenia. In a pilot investigation, we administered minocycline as an open-label adjunct to antipsychotic medication to patients with schizophrenia. The results of this trial suggested that minocycline might be a safe and effective adjunct to antipsychotic medications, and that augmentation with minocycline may prove to be a viable strategy for "boosting" antipsychotic efficacy and for treating schizophrenia. The present review summarizes the available data supporting the clinical testing of minocycline for patients with schizophrenia. In addition, we extend our discussion to the potential applications of minocycline for combining this treatment with cellular and molecular therapy.

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    • "Pleiotropic properties of minocycline targeting multiple proteins and cellular processes implicated in the pathoetiology of mood disorders make it a suitable candidate for treatment of depression (Soczynska et al., 2012). It may be a valuable adjunctive therapeutic agent to antipsychotic medication in patients with schizophrenia as well (Miyaoka, 2008). In a clinical ad-on trial, minocycline treatment of early-phase schizophrenia patients improved negative symptoms and cognitive functions (Levkovitz et al., 2010). "
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    • "Minocycline, a brain-penetrable antibiotic (Fagan et al., 2004) is capable of modifying brain functioning in conditions ranging from neurodegeneration (Chu et al., 2010; Elewa et al., 2006; Li et al., 2009) to psychiatric disorders (Miyaoka et al., 2008; Neigh et al., 2009; Pae et al., 2008) and addiction (Chen et al., 2009; Habibi-Asl et al., 2009; Kofman et al., 1990; Sofuoglu et al., 2009). Some of these minocycline actions have been attributed to its ability to inhibit the 5-LOX pathway (Chu et al., 2007, 2010; Song et al., 2004, 2006). "
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