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An arthroscopic technique to treat the iliotibial band syndrome

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Iliotibial band syndrome (ITBS) is an overuse injury mainly affecting runners. The initial treatment is conservative. Only, in recalcitrant cases surgery is indicated. Several open techniques have been described. The purpose of this study is to evaluate the results of a standardized arthroscopic technique for treatment of a resistant ITBS. Thirty-six athletes with a resistant ITBS were treated with a standardized arthroscopic technique, limited to the resection of lateral synovial recess. Thirty-three patients were available for follow-up (mean 2 years 4 months). Thirty-two patients (34 knees) had good or excellent results. All patients went back to sports after 3 months. In two patients a meniscal lesion was found, which required treatment. One patient with only a fair result had associated cartilage lesions of the femoral condyle. Our results show that arthroscopic treatment of resistant ITBS is a valid option with a consistently good outcome. In addition, this arthroscopic approach allows excluding or treating other intra-articular pathology.
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KNEE
An arthroscopic technique to treat the iliotibial band syndrome
F. Michels ÆS. Jambou ÆM. Allard ÆV. Bousquet Æ
P. Colombet ÆC. de Lavigne
Received: 9 May 2008 / Accepted: 15 October 2008
ÓSpringer-Verlag 2008
Abstract Iliotibial band syndrome (ITBS) is an overuse
injury mainly affecting runners. The initial treatment is
conservative. Only, in recalcitrant cases surgery is indi-
cated. Several open techniques have been described. The
purpose of this study is to evaluate the results of a stan-
dardized arthroscopic technique for treatment of a resistant
ITBS. Thirty-six athletes with a resistant ITBS were treated
with a standardized arthroscopic technique, limited to the
resection of lateral synovial recess. Thirty-three patients
were available for follow-up (mean 2 years 4 months).
Thirty-two patients (34 knees) had good or excellent
results. All patients went back to sports after 3 months. In
two patients a meniscal lesion was found, which required
treatment. One patient with only a fair result had associated
cartilage lesions of the femoral condyle. Our results show
that arthroscopic treatment of resistant ITBS is a valid
option with a consistently good outcome. In addition, this
arthroscopic approach allows excluding or treating other
intra-articular pathology.
Keywords Iliotibial tract Knee arthroscopy
Arthroscopic treatment Lateral synvial recess
Iliotibial band syndrome
Introduction
Iliotibial band syndrome (ITBS) is an overuse injury
mainly affecting runners [5]. The symptoms range from a
stinging sensation just on the outside of the knee to
swelling or thickening of the tissue at the point where the
band moves over the femur. ITBS can usually be treated
conservatively. Sometimes the ITBS is resistant to con-
servative therapy and surgery may be necessary. The
conventional technique is lengthening of the iliotibial band
(ITB) and removing a section of the posterior aspect of the
ITB [3,4,8]. Most reports of surgical treatment are limited
by a small number of patients [3,811]. Though, Drogset
et al. [1] evaluated 45 patients, and found 84.5% good to
excellent results.
An arthroscopic technique was developed for several
reasons. First, the exact pathogenesis of the ITBS is still
controversial. Earlier studies refer to excessive friction
between the tract and the lateral femoral condyle, which
causes inflammation of an underlying bursa ITBS [3,4,8].
Newer studies question this hypothesis. Recent anatomic
and microscopical studies concluded that the ITBS was
anchored to the distal femur by fibrous strands, associated
with a layer of richly innervated and vascularised fat [2,7].
Nemeth and al labelled it the lateral synovial recess [7]. In no
cadaver, volunteer or patient a bursa was seen. Fairclough
and al suggest that movement and friction of the ITB is an
illusion and they consider it as a form of enthesopathy. MRI
studies showed correlation between the ITBS and signal
intensity alterations in the fatty tissue deep to the ITB [2,6].
Our hypothesis is the following: if the inflammation is
limited to the fibrous attachments to the femur and the
surrounding fat, there’s no need to resect a part of the ITB.
Second, an intra-articular problem can mimic an ITBS
[6]. Muhle et al. found three meniscal tears on MRI in 16
F. Michels (&)
Gladiatorenstraat 29, 8510 Kortrijk, Belgium
e-mail: frederick_michels@hotmail.com
S. Jambou M. Allard V. Bousquet P. Colombet
C. de Lavigne
Bordeaux Me
´rignac Sports Clinic, 9 rue Jean Moulin,
33700 Bordeaux-Me
´rignac, France
123
Knee Surg Sports Traumatol Arthrosc
DOI 10.1007/s00167-008-0660-5
patients with clinical signs of ITBS [6]. Richards et al. [9]
recommend performing an associated arthroscopy to
address any intra-articular pathology. This is also possible
with an arthroscopic technique treating ITBS.
Finally, an arthroscopic technique may be less invasive
than an open technique.
Based on these findings we used an arthroscopic tech-
nique limited to the resection of the fibrous attachments to
the femur and the associated fat. The purpose of this ret-
rospective study is to evaluate the results of this technique
in a group of patients with a resistant ITBS.
Material and methods
Study population
From 2003 through 2007, 36 patients underwent 38 pro-
cedures for ITBS at the Bordeaux Merignac Sports Clinic.
Thirty-three patients (35 knees) were available for follow-
up. All patients had at least 6 months follow-up with an
average of 2 years 4 months. There were 15 women and 21
men. The mean age was 31.1 years (range 19–44). In 16
patients the right knee was affected, in 22 patients the left
knee, which includes two patients affected bilaterally.
All the patients had been treated conservatively during
at least 6 months. The conservative treatment consisted of
rest, correction of training error, shoe modification, phys-
iotherapy and local infiltration with steroids.
On average the patients had suffered from the ITBS for
18 months preoperatively (range 1–7 years). All the
patients were recreational or professional athletes: long
distance running (22), triathlon (5), cycling (4), athletics
(3), rugby (3), soccer (1), swimming (1), fencing (1) and
basketball (1). The diagnosis was based on clinical find-
ings. In all patients an ultrasonography or an MRI was
performed in an attempt to exclude other pathology.
Operation technique
We used a standardized arthroscopic technique. The patient
is placed in supine position under general or spinal
anaesthesia. Two supports are placed to keep the leg in 30
degrees of flexion, corresponding to the position in which
the ITB is compressed against the lateral condyle [2]. A
thigh tourniquet is used. Through an anteromedial portal
and an anterolateral portal the joint space is inspected and
other possible lesions are searched for and treated if
needed.
The lateral gutter is inspected. In all patients a lateral
synovial recess was found. A needle is placed percutane-
ously in this synovial recess (Fig. 1). With the knee in 30°
flexion, this recess corresponded in all the patients with the
lateral femoral epicondyle. A superolateral portal is used as
a working portal. The lateral synovial recess is debrided
with the synovial shaver (Fig. 2). The resection is com-
pleted when the bone on the lateral femoral condyle is
visible. The whole procedure is performed intra-articularly.
A drain is placed during 24 h. Postoperatively early range
of motion exercises and full weight bearing is promoted.
Slow running was allowed two months postoperatively.
Results
Two months postoperatively 74.2% was able to start slow
running, this was 100% at check-up 3 months
postoperatively.
The subjective functional results after surgery were
assessed with the score used by Drogset et al. [1]. There
were 28(80%) excellent results, 6(17.1%) good results,
1(2.9%) fair result and no poor results.
Satisfaction was assessed using the visual analogue
scale, anchored at 0 for lowest and 10 for highest satis-
faction. Patients were generally satisfied with scores
ranging from 6 to 10 points (mean 9). Had the
Fig. 1 Arthroscopic view of lateral gutter with needle in synovial
recess
Fig. 2 Arthroscopic view of lateral gutter during resection of
synovial recess with synovial shaver
Knee Surg Sports Traumatol Arthrosc
123
postoperative result been known beforehand, all but one of
the patients would have been operated on again.
Associated lesions
The only patient with a fair result had associated cartilage
lesions of the femoral condyle.
In two patients a meniscal lesion was found, which
required treatment. The lesions had not been noticed on the
preoperative MRI. In one patient a calcified loose body was
found trapped in the lateral synovial recess and resected
arthroscopically.
Complications
One patient developed a haematoma that required evacu-
ation four days postoperatively. Finally the patient healed
without complications.
Discussion
The most important finding of the present study was that
the arthroscopic treatment is a suitable and reproducible
technique with good results.
The initial treatment of the iliotibial band syndrome
consists of activity modification, a trial of anti-inflamma-
tory, local modalities, stretching, physical therapy, shoe
modification, and possibly a cortisone injection. Only in
recalcitrant cases surgery is indicated [1,4,8,10].
Several open techniques have been described to dimin-
ish the tension on the posterior part. In 1979 Noble et al. [8]
described a 2-cm incision across the fibers of the posterior
iliotibial band at the level of the lateral epicondyle. Holmes
et al. [3] resected an elliptical portion of the posterior ITB.
Martens et al. did a triangular resection [4]. Drogset et al.
[1] did a more extensive resection. They published a ret-
rospective study of 45 patients with good or excellent
results in 84.5% of the patients. In this study we had 97.1%
good or excellent results with the same rating scale.
Sangkaew reported a mesh technique in a case report [10].
Richards et al. [9] performed a Z-lengthening associated
with a diagnostic arthroscopy.
The exact pathogenesis of the ITBS is still controversial.
The iliotibial band syndrome was believed to be associated
with excessive friction between the tract and the lateral
femoral condyle which inflames the tract or bursa [3,4,8].
In 1996, in a cadaver study, Nemeth and Sanders found
that this sac, is actually a lateral extension of the joint cap-
sule and suprapatellar synovial cavity of the knee joint [7].
Biopsies of this lateral recess in patients with ITBS showed
histopathologic changes consisting of chronic inflammation,
hyperplasia, fibrosis and mucoid degeneration [7].
In 1999, the MRI study of Muhle et al. [6] revealed
correlation between the ITBS and signal intensity altera-
tions in the fatty tissue deep to the ITB. Similar MR signal
changes were found by other authors [2]. The ITB dem-
onstrated normal signal intensity on all MR images [6].
The cadaver study Fairclough et al. [2] in 2006 found
that the ITB was firmly anchored to the distal femur by
fibrous strands, associated with a layer of richly innervated
and vascularised fat. This femoral anchorage prevents the
ITB from rolling over the epicondyle. They suggest that the
perception of movement of the ITB across the epicondyle
is an illusion because of changing tension in its anterior and
posterior fibres. Because ITB overuse injuries may be more
likely associated with fat compression beneath the tract,
they consider it as a form of enthesopathy.
The arthroscopic technique in this study was limited to
the resection of the fibrous attachments to the femur and
the associated fat. The good results of this treatment con-
firm the hypothesis that the inflammation is limited to the
fibrous attachments to the femur and the surrounding fat.
No resection of the ITB is needed.
In addition, this arthroscopic approach allows excluding
and treating other intra-articular pathology. In this study
two patients had meniscal lesions requiring treatment; one
patient had important cartilage lesions.
Calcified loose bodies trapped in the lateral synovial
recess are already described by Tomlinson et al. [11].
However, with our technique we succeeded to remove the
fragments arthroscopically.
Because of the risk of haematoma we recommend to
deflate the tourniquet before closure and achieve haemo-
stasis if needed. We leave a drain during 24 h.
In conclusion, ITBS is an overuse syndrome mainly
affecting runners. We emphasize that a prolonged nonop-
erative trial must be attempted before surgery. The
presented study shows that the arthroscopic treatment is a
suitable and reproducible technique with good results. In
addition it allows assessment and treatment of any intra-
articular pathology.
References
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... Open surgery include the resections initially described by Nobel [10], Martens et al. [11], Drogset et al. [12] and Holmes et al. [13], or more recent techniques such as Z-plasty lengthening [14] and bursectomy in cases of recalcitrant ITBS [15]. Less invasive options include percutaneous lengthening of the ITB, arthroscopic debridement of the lateral synovial recess [4,16,17], and a combination of both [18]. ...
... Results consistent with those of our own study have been previously reported in the literature. Michels et al. [16] presented the results of a series of 33 patients subjected to debridement of the lateral synovial recess using a totally intraarticular arthroscopic technique. All patients were able to perform slow running three months after the operation, 80% reported excellent outcomes, and 17% good outcomes, based on the functional scale of Drogset et al. [12] Cowden and Barber [4] described a similar procedure in a single 41-year-old male who ran marathons and was able to return to athletic activity without discomfort after the pain disappeared four weeks following surgery. ...
Article
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Introduction Description of a new surgical procedure (percutaneous lengthening and arthroscopic release, PLAR) that combines all the possible interventions on the iliotibial band (ITB), and evaluates its outcomes in a group of distance runners diagnosed with ITBS. Methods A prospective observational study was made of distance runners diagnosed with ITBS and operated upon using the PLAR technique between 1 and 2018 and 31 June 2020. The surgical technique is described in detail, and the demographic data and functional outcomes measured by the sports performance scales Activity Rating Scale (ARS) and International Knee Documentation Committee (IKDC) are presented. Results A total of 14 patients were included, with a mean follow-up of 16 months (range 12–42 months). All the patients resumed their previous sporting activity after an average of 4 (range 2.5-6) months, and no complications were recorded. In all cases, statistically significant improvement was evidenced by the ARS and IKDC scales following PLAR (p < 0.001), with excellent outcomes in 71% of the cases according to the ARS scale and in 86% according to the IKDC scale (mean difference between preoperative and final follow-up scores of 12.1/16 and 34.2/100 points, respectively). Conclusion The PLAR technique is effective in allowing a return to previous sports performance levels in a short period of time among patients with ITBS refractory to conservative management, with a high satisfaction rate and the absence of complications.
... To the best of our knowledge, seven other studies, composed of similar cohort sizes, published so far results of their surgical techniques to treat tenacious ITB friction syndrome 2,11,12,20,21,22,23) Martens et al. performed an ellipsoid excision of the ITB and showed that after a mean duration of 7 weeks, all patients could return to sport, with 100% satisfaction and a Lysholm score of 85.86 2 . In our study, the final results were similar (Lysholm score of 87.7 and 93% satisfaction) but delayed as reflected by the lower short term Lysholm score after 6 weeks (62.9) and return to sport after 23.8 weeks (6 up to 52 weeks). ...
... Michels et al. treated 33 patients by an arthroscopic lengthening of the ITB. After an average of 12 weeks, all of them returned to sports with 97% patient satisfaction and only 1 (3%) hematoma 22 . The minimal invasive character of the intervention possibly explains the quicker return to sport compared to our group despite the similar mean age, as well as the lower complication rate. ...
Article
In this retrospective study, a technique consisting in neurolysis of the lateral retinacular nerve combined with a partial release through elliptic excision of the iliotibial band (ITB) is evaluated for efficacy in recalcitrant ITB friction syndrome and compared with results from other techniques reported in literature. From April 2014 to December 2017, 21 patients suffering from recalcitrant ITB friction syndrome were surgically treated with the aforementioned technique. 15 patients (15 knees) were available for a written retrospective reassessment after completion of a follow-up period of at least 12 months. Residual pain was scored using the Visual Analogue Scale (VAS). The functional outcome was evaluated by two patient reported outcome measurement scales (PROMs), the Lysholm and the International Knee Documentation Committee (IKDC) score. Return to sport was analysed by duration of the inactivity period as well as by the Tegner score. Overall satisfaction was evaluated using a modified Boyden scale. At final follow-up of one year, the performed intervention resulted in a pain reduction (VAS 4.2 (1-8) to 1.4 (0-6)) and improved knee function (Lysholm 59.53 to 87.73, IKDC 75) with return to sport (Tegner 4.3 to 5.4) after a median of 23.8 weeks (6 to 52). Twelve patients reported good or excellent results (80%) at final follow-up, and 12 patients (80%) would undergo surgery again, if necessary. The treatment of recalcitrant ITB friction syndrome by combining neurectomy of the lateral retinacular nerve with elliptic excision of the ITB resulted in good to excellent results in 80% of treated cases with return to sport in 93%.
... Open surgery includes the resections initially described by Nobel (8) , Martens et al. (9) , Drogset et al. (10) and Holmes et al. (11) , or more recent techniques such as Z-plasty lengthening (12) and bursectomy in cases of recalcitrant ITBS (13) . Less invasive options include percutaneous lengthening of the ITB and arthroscopic debridement of the lateral synovial recess (4,14,15) . ...
... Michels et al. (14) presented the results of a series of 33 patients subjected to debridement of the lateral synovial recess using a totally intraarticular arthroscopic technique. All patients were able to perform slow running three months after the operation, 80% reported excellent outcomes, and 17% good outcomes, based on the functional scale of Drogset et al. (10) Cowden and Barber (4) described a similar procedure in a single 41-year-old male who ran marathons and was able to return to athletic activity without discomfort after the pain disappeared four weeks following surgery. ...
Preprint
Full-text available
Introduction Description of an arthroscopic procedure (all-inside arthroscopic release, AIAR) that combines all the possible interventions on the iliotibial band (ITB), and evaluates its outcomes in a group of distance runners diagnosed with ITBS. Methods A prospective observational study was made of distance runners diagnosed with ITBS and operated upon using the AIAR technique between 1 January 2018 and 31 June 2020. The surgical technique is described in detail, and the demographic data and functional outcomes measured by the ARS and IKDC sports performance scales are presented. Results A total of 14 patients were included, with a mean follow-up of 16 months (range 12–42 months). In all cases, statistically significant improvement was evidenced by the ARS and IKDC scales following AIAR (p = 0.00048), with excellent outcomes in 71% of the cases according to the ARS scale and in 86% according to the IKDC scale (mean difference of 11.9/16 and 33.8/100 points, respectively). No complications were recorded. Conclusion The AIAT technique is effective in allowing a return to previous sports performance levels in a short period of time among patients with ITBS refractory to conservative management, with a high satisfaction rate and the absence of complications.
... ITBS is mainly treated conservatively, and is based on rest, ice, and nonsteroidal anti-inflammatory drugs associated with physical therapy focusing on stretching the ITB and thigh lateral structures, strengthening hip abductors, neuromuscular control, and improving function. 1,3,5,7,[11][12][13] Local steroids injections can be used when other conservative measures have failed to confer clinical improvement. 1,4,6,10,13 More than 90% of the patients respond favorably to these nonoperative measures 11,14 and return to sports after 3 to 4 months. ...
... 1,4,6,10,13 More than 90% of the patients respond favorably to these nonoperative measures 11,14 and return to sports after 3 to 4 months. 9,12,15 In those cases refractory to conservative treatment (usually after 3-6 months), surgical intervention is advocated. [1][2][3][4][5] Multiple surgical options to treat ITBS have been described, including open and arthroscopic techniques (Table 1). 2 However, these techniques aim either to release the ITB or to reduce inflammation by excision of underlying bursal tissue without considering a multifactorial etiology. ...
Article
Full-text available
Multiple surgical techniques have been described to treat refractory iliotibial band syndrome. However, there is lacking evidence demonstrating superiority of one technique over the other and limited audiovisual resources. Most surgical procedures aim to release the iliotibial band; nevertheless, few focus on reducing concomitant inflammation. The present article illustrates a Z-plasty lengthening technique associated with local bursectomy for treating iliotibial band syndrome refractory to conservative treatment.
... In this case, surgery is needed, and is shown to be very effective (100% recovery) (Beals and Flanigan 2013). The surgical treatment can be as follows: arthroscopic technique (resection of the fibrous attachments to the femur and the associated fat, without a resection of the ITT) (Michels et al. 2009); surgical release of the posterior fibers of the ITT by a 2-cm incision at the level of ITT's tibial insertion (Noble 1979); the excision of abrading posterior distal ITT fibers (Holmes, Pruitt, and Whalen 1993); mesh technique (Sangkaew 2007), which may also be named in the literature as a pie-crusting (PC) technique and represents itself as small (one-two millimeter long) multiple incisions (perpendicular to the fibers of the ITT in the area overlying the lateral femoral epicondyle) (Bruzzone et al. 2010;Elkus et al. 2004;Jabalameli et al. 2016;He, Cai, and Zhang 2018;Politi and Scott 2004), and more others. ...
Thesis
There are many sports-related knee injuries, some of which involve the iliotibial band (ITT). This is a thicker part of the deep fascia of the thigh, called fascia lata. The fascia lata is a fibrous connective tissue composed of elastin fibers and networks of collagen fibers present in different layers of tissue. It has a stabilizing role in the joint and allows the transfer of forces between muscles, but its properties and strain mechanisms remain poorly understood. In this context, the strain mechanisms of the fascia lata during physiological knee movements were studied. Quantitative data of fascia lata strain fields were obtained in situ highlighting strain mechanisms in tension, compression, and shear. Therefore, the mechanical behavior of isolated fascia lata samples was analyzed with shear tests such as bias extension tests and traction of a large band tissue. The study of collagen fiber kinematics was also included. A first contribution to the finite element modelling of fascia behavior was also proposed. Finally, as the natural state of deformation of the fascia lata contributes to good knee mobility, an in situ study was set up to evaluate the impact on joint mobility and strain levels on fascia of a surgical tension-release technique, known as pie-crusting, applied to the ITT and which may be recommended in pathological cases. All the work carried out therefore provides new elements in the study of the mechanical behavior of fascia lata.
Chapter
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The objectives of our study were: 1) to examine differences between a noninjured cohort of runners (N = 70) and runners afflicted with iliotibial band friction syndrome (ITBFS) (N = 56) according to selected anthropometric, biomechanical, muscular strength, and training measures; 2) to explore multivariate relationships among these measures in both the well and injured groups; and 3) to develop specific hypotheses concerning risk factors for injury that will later be tested in a prospective observational study. High speed videography (200 fps), a force platform (500 Hz), and a Cybex II+ isokinetic dynamometer were used to assess rearfoot motion, ground reaction forces, and knee muscular strength and endurance, respectively. A linear discriminant function analysis of the training data revealed weekly mileage, training pace, number of months using current training protocol, % time spent swimming, and % time spent running on a track to be significant (P < 0.10). Height was a significant anthropometric discriminator, while seven isokinetic strength and endurance measures were found to discriminate significantly between the groups. Calcaneal to vertical touchdown angle, and maximum supination velocity were significant rearfoot movement discriminators. Maximum braking force was the only significant kinetic discriminator. A combined discriminant analysis using those variables found to be significant in the previous analyses revealed weekly mileage, and maximum normalized braking force to be the best discriminators (model P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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Iliotibial band syndrome is an overuse injury caused by repetitive friction of the iliotibial band across the lateral femoral epicondyle. Once considered an injury indigenous to runners, it is now frequently being seen in cyclists. The purpose of this paper is to identify iliotibial band syndrome as a significant problem in cyclists and to propose both operative and nonoperative measures for treating cyclists. Nonoperative measures specific to cyclists consist of bicycle adjustments and training modifications. These are adjunctive therapies to stretching, icing, rest, and oral nonsteroidal antiinflammatory drugs. For cyclists requiring operative intervention, a new surgical technique for excising or releasing the distal iliotibial band is presented. This technique, used by the senior author (JCH) since 1984, involves excision of an elliptical piece of the distal posterior band off the lateral femoral epicondyle.
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A survey of 123 distance-running coaches and their best runners was undertaken to describe prescribed seasonal training and its relationship to the performance and self-reported training of the runners. The runners were 43 females and 80 males, aged 24 +/- 8 years (mean +/- S.D.), training for events from 800 m to the marathon, with seasonal best paces of 86 +/- 6% of sex- and age-group world records. The coaches and runners completed a questionnaire on typical weekly volumes of interval and strength training, and typical weekly volumes and paces of moderate and hard continuous running, for build-up, pre-competition, competition and post-competition phases of a season. Prescribed training decreased in volume and increased in intensity from the build-up through to the competition phase, and had similarities with 'long slow distance' training. Coaches of the faster runners prescribed longer build-ups, greater volumes of moderate continuous running and slower relative paces of continuous running (r = 0.19-0.36, P < 0.05), suggesting beneficial effects of not training close to competition pace. The mean training volumes and paces prescribed by the coaches were similar to those reported by the runners, but the correlations between prescribed and reported training were poor (r = 0.2-0.6). Coaches may therefore need to monitor their runners' training more closely.
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The tissue deep to the iliotibial band (ITB) and its relationship to the lateral knee joint capsule was studied anatomically and the histopathology of this tissue in chronic iliotibial band friction syndrome (ITBFS) was examined. Findings show that the tissue under the ITB consists of a synovium that is a lateral extension and invagination of the actual knee joint capsule and is not a separate bursa as described in the literature. Additionally, in cases of chronic ITBFS seen in young elite athletes, synovial tissue taken from this lateral synovial recess reveals histological evidence of inflammation and hyperplasia that suggests its involvement in the pathological process.
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To define magnetic resonance (MR) imaging findings in patients with the iliotibial band friction syndrome (ITBFS) and to correlate these findings with anatomic features defined at magnetic resonance (MR) arthrography in cadavers. The anatomic relationship of the iliotibial tract (ITT) to the lateral recesses of the knee joint and the lateral femoral epicondyle was investigated with MR arthrography at full extension and at 30 degrees and 60 degrees of knee flexion in six cadaveric knees. Seventeen MR imaging studies in 16 patients with ITBFS were evaluated. In the cadaveric study, no interference of the lateral synovial recess with the lateral femoral epicondyle at full extension and at 30 degrees and 60 degrees of knee flexion was observed. In all specimens, correlation of MR images with macroscopic and microscopic sections revealed no primary bursa between the lateral femoral epicondyle and the ITT. In clinical studies, MR imaging findings of poorly defined signal intensity abnormalities or circumscribed fluid collections were located in a compartmentlike space confined laterally by the ITT and medially by the meniscocapsular junction, the lateral collateral ligament, and the lateral femoral epicondyle. MR imaging accurately depicts the compartmentlike distribution of signal intensity abnormalities in patients with ITBFS.