Balanites aegyptiaca is an edible fruit bearing tree of arid and semi-arid regions. It has been used by humans since ancient times as a source of food and for other ethnobotanical and ethnomedicinal purposes. Many review articles were published about this tree, and we will present the most important of them, to explain why this review article is the most important. The number of the medicinal activities of Balanites aegyptiaca is relatively large and these include antidiabetic, antimicrobial, antioxidant, antiparasitic, hepatoprotective, wound healing and nutritional. The chemical composition of this tree was extensively studied and published and the publications will be summarized in this article. In the discussion section, various factors that affect the quality of the tree products will be presented, in addition to its economic value and its use in the preparation of nanoparticles that have notable medicinal activities. In the last part, conclusions will be drawn and suggestions future research and uses will be proposed. Abbreviations: ABTS 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), ahc and her/his colleagues, AChE acetylcholine esterase, BuChE butyrylcholine esterase, COX cyclooxygenase, DPPH 2,2-Diphenyl-1-picrylhydrazyl, DCM dichloromethane, EO essential oil, FRAP ferric reducing activity power, GC-MS gas chromatography mass spectrometry, GSH glutathione, LC-MS liquid chromatography mass spectrometry, LPS lipopolysaccharide, LOX lipoxygenase, MDA malondialdehyde, NPs nanoparticles, OSI oxidative stress index, PE petroleum ether, PLA phospholipase, STZ streptozotocin, TAC total antioxidant capacity, TAR total antioxidant response, TBARS thiobarbituric acid reactive substances, TEAC Trolox equivalent antioxidant capacity, TFC total flavonoid content, TOS total oxidative status, TPC total phenolic content, TTC total tannins content.