Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis

Department of Pharmacology, Govt. Medical College, Rajkot, India.
Journal of Pharmacology and Pharmacotherapeutics 10/2012; 3(4):300-3. DOI: 10.4103/0976-500X.103685
Source: PubMed


To explore the effect of vitamin D supplementation in prevention of respiratory tract infections on the basis of published clinical trials.
Clinical trials were searched from various electronic databases. Five clinical trials were suitable for inclusion. Outcome was events of respiratory tract infections in vitamin D group and placebo group. Data was reported as odds ratio with 95% confidence interval. Both random and fixed model was used for analysis. Analysis was done with the help of Comprehensive meta-analysis software 2.
Events of respiratory tract infections were significantly lower in vitamin D group as compared to control group [Odds ratio = 0.582 (0.417 - 0.812) P = 0.001] according to random model. Results were similar in fixed model. On separate analysis of clinical trials dealing with groups of children and adults, beneficial effect of vitamin D was observed in both, according to fixed model [Odds ratio = 0.579 (0.416 - 0.805), P = 0.001 and Odd ratio = 0.653 (0.472 - 0.9040, P = 0.010 respectively]. On using random model beneficial effect persisted in children's group but became nonsignificant in adults group [Odds ratio = 0.579 (0.416 - 0.805), P = 0.001 and Odd ratio = 0.544 (0.278 - 1.063) P = 0.075 respectively].
Vitamin D supplementation decreases the events related to respiratory tract infections. There is need of more well conducted clinical trials to reach to a certain conclusion.

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    • "In addition to promoting the absorption of calcium and phosphorus in the mucosa of small intestine and regulating the deposition and release of bone calcium, it can also participate in the differentiation and regulation of the immune system to play its biological activity. Related reports indicate that the immune mechanism of bronchial asthma is regulated by many factors, and the 1,25-(OH) 2 D 3 can improve the symptoms of chronic airway inflammation in asthma, with a significant negative correlation between them [1] [2] [3] [4] . There is close relationship between the type I allergy and the incidence of asthma. "
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    • "Patients who showed prehospital vitamin concentrations of less than 10 ng/mL were significantly correlated with increased odds of developing HABSI [43]. A meta-analysis published by Charan et al. (2012) evaluated five clinical trials. The outcome events were URTIs in the vitamin D group and the placebo group. "
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