A verocytotoxin-producing E. coli outbreak with a surprisingly high risk of haemolytic uraemic syndrome, Denmark, September-October 2012

Department of Infectious Disease Epidemiology, Statens Serum Institut, Copenhagen, Denmark.
Eurosurveillance: bulletin europeen sur les maladies transmissibles = European communicable disease bulletin (Impact Factor: 5.72). 01/2013; 18(2).
Source: PubMed


Denmark faced an outbreak of verocytotoxin-producing E. coli (VTEC) O157:H7 infections in autumn 2012. Thirteen cases were diagnosed of which eight had haemolytic uraemic syndrome (HUS). Epidemiological investigations suggested ground beef as the vehicle of the outbreak. The outbreak strain had a rare toxin gene subtype profile: eae, vtx1a and vtx2a, and a high proportion of HUS (62%) among cases, a finding previously linked with the outbreak subtype profile. Toxin subtyping can be useful to identify high risk VTEC strains.

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Available from: Flemming Scheutz, Sep 21, 2015
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    • "Nevertheless, there are certain serotypes that can cause diseases in humans and animals [6] [7]. Verocytotoxinproducing Escherichia coli (VTEC) is a serious public health concern as it has been responsible for outbreaks in European countries [8] [9] and has been associated with haemolyticuraemic syndrome (HUS), the leading cause of acute renal failure in children [7] [10]. On the other hand, VTEC could also colonize the human intestine without causing any symptoms [6] [11]. "
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