Pattern of Uveitis in a University-based Referral Center in Southern Thailand

ArticleinOcular immunology and inflammation 21(1):38-45 · February 2013with20 Reads
DOI: 10.3109/09273948.2012.730651 · Source: PubMed
Purpose: To identify the characteristics (demographics, anatomical classification, diagnoses, and treatment) of all uveitis patients who were seen at our newly started Uveitis and Ocular Inflammatory Disease Clinic over a two-year period. Methods: The computerized uveitis database files and medical records for all new consecutive patients seen at our Uveitis and Ocular Inflammatory Disease Clinic from January 2010 through December 2011 were included. Results: A total of 254 patients were seen during the study period. Anterior uveitis and panuveitis were most frequently found, each accounting for around 35% of cases. Specific diagnoses were established in 70.9% of patients and the top five most common specific diagnoses were VKH (11%), HLA-B27-associated anterior uveitis (7.9%), Behçet disease (7.1%), toxoplasmosis (7.1%), and herpetic anterior uveitis (4.7%). Conclusion: In this setting, the authors found VKH to be the most common diagnosis in the noninfectious uveitis group. Regarding infectious uveitis, toxoplasmosis ranked the most common diagnosis.
    • "These comprised cases such as anterior uveitis, Posner Schlossman syndrome, systemic lupus erythematosus-associated retinopathy, and toxoplasmosis, which are often treated by general ophthalmologists or other subspecialty ophthalmologists . Because CMVR related to AIDS patients has occupied a large proportion of the etiology of posterior uveitis, and as it was treated in a separate specialty4,11,13,15,17,19,22,27 The only studies on this entity that have unveiled frequent data are European ones. 16,20 In contrast to Asia, posterior uveitis was found to be the second most common subtype in studies done in the United States 22 and Tunisia. "
    [Show abstract] [Hide abstract] ABSTRACT: Abstract Purpose: To report the pattern of uveitis in a major ophthalmology center in the central district of Thailand. Methods: A retrospective study was performed in uveitis cases visiting the Department of Ophthalmology at Rajavithi Hospital, Thailand, from January 2007 to October 2012. Results: Four hundred and forty-six patients (mean age 42 years, female 53.8%) were included in the study. Uveitis was unilateral in 51.1% of cases. Anterior uveitis was the most common (44.8%) case, closely followed by panuveitis (40%), posterior uveitis (14.3%), and intermediate uveitis (0.9%). Specific diagnosis was established in 51.6% of patients. The three most common specific diagnoses were Vogt-Koyanagi-Harada (VKH) disease (22.4%), followed by Behçet disease (6.7%) and herpetic anterior uveitis (5.8%). Conclusions: The most common type of noninfectious uveitis group was VKH, while herpetic anterior uveitis was the most common type of infectious uveitis in the central district of Thailand.
    Full-text · Article · Aug 2014
    • "Les principales étiologies des panuvéites associées à une maladie de système sont la sarcoïdose (10 à 20 %), la maladie de Behçet et la maladie de VKH [13—15] . Les causes infectieuses sont essentiellement représentées par la tuberculose, la toxoplasmose et les rétinites virales nécrosantes [15,16]. Dans notre série, les étiologies étaient dominées par la forme idiopathique (50,9 %), la maladie de Behçet (22,4 %) et la toxoplasmose (12,1 %). "
    Full-text · Article · Aug 2013
  • [Show abstract] [Hide abstract] ABSTRACT: To report the clinical features of patients with focal chorioretinitis (FCR), as well as toxoplasma serology. We included 25 (4%) consecutive patients with FCR of 593 with uveitis. Controls consisted of 127 patients with posterior and panuveitis and clinical features other than FCR. Results of enzyme-linked immunosorbent assay for anti-Toxoplasma gondii immunoglobulin G (IgG) and IgM, demographic data, and clinical features of patients were registered. Positive anti-T. gondii IgG levels were observed in 21 of 25 patients (84%) with FCR in contrast to 14 of 127 patients (11%) with non-FCR (P < 0.001, Fisher test). The IgG levels >600 IU were found in 19 of 25 patients (76%) with FCR and in none of the patients with non-FCR (P < 0.001). All cases had unilateral involvement. Ocular features consisting of FCR and vitritis were present in all patients, but associated chorioretinal atrophic scars were not commonly seen (7/25 eyes; 28%). Retinal vasculitis was found in 9 of 25 eyes (36%) and affected solely the arteries. The majority of patients with FCR in Thailand exhibit highly positive anti-T. gondii IgG levels suggesting the presence of active systemic infection, which is also consistent with the absence of old scars. The absence of old scars and retinal arteritis were the features distinct from typical ocular toxoplasmosis lesions reported in the European and the U.S. series.
    Article · Aug 2013
Show more