Abstract One core characteristic of the Textile and Clothing Industry (TCI) is networking. The Extended Smart Garment Organization (xSGO) framework will improve the inter-organisational knowledge networking in a holistic way. Apply-ing this xSGO framework, a new quality (of) partnership in the textile and cloth-ing value creation chain will be enabled. The xSGO framework comprises a configuration toolset, which allows to model and analyze an existing network for innovation and production, and to select and configure appropriate measures in order to improve the integration of activities and actors. Integrative components enable knowledge communication based on Moda-ML, and involve adapted RFID technologies, combined with a system for Product Tracing and Tracking. In particular fast ramp up of new garment products in supply networks is conceptually and methodically improved. This paper gives an overview about the holistic, system-oriented xSGO frame-work, explains details of Quality Harmonization as one major component, and presents results of practical applications in the Textile and Clothing Industry.