Association of Marine-Origin n-3 Polyunsaturated Fatty Acids Consumption and Functional Mobility in the Community-Dwelling Oldest Old.

M. Takayama, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582 Japan, E-mail address: , TEL: +81-3-3353-1211 (ext. 62915), FAX: +81-3-5269-2468.
The Journal of Nutrition Health and Aging (Impact Factor: 3). 01/2013; 17(1):82-9. DOI: 10.1007/s12603-012-0389-1
Source: PubMed


Objective: To examine whether habitual dietary intake of marine-origin n-3 polyunsaturated fatty acids (MOPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with functional mobility in the community-dwelling oldest old, 85 years or older, who are at high risk for physical disability. Design: A cross-sectional study. Setting: A community-based survey conducted at university research center or home-based. Participants: Four hundred seventeen (189 men, 228 women) out of 542 participants in the baseline examination of the Tokyo Oldest Old Survey on Total Health, a community-based ongoing longitudinal study among the oldest old living in the center of Japan. Measurements: Habitual dietary intake of MOPUFA was assessed by the brief-type self-administered diet history questionnaire (BDHQ), and functional mobility was assessed by the Timed Up and Go test. Plasma inflammatory biomarkers (C-reactive protein, interleukin-6 and tumor necrosis factor-α) were measured. We evaluated the cross-sectional association between habitual intake of MOPUFA and functional mobility using multivariate logistic regression analysis. Prior to the analysis, validation of BDHQ in this study was confirmed among 190 participants (96 men, 94 women) based on the EPA and DHA concentrations in the erythrocyte membrane phospholipids as reference. Results: Moderate correlation between estimated dietary intake of EPA/DHA and concentration of EPA/DHA in the erythrocyte membrane phospholipids was obtained (Spearman's r=0.29-0.58, p<0.01). Multivariate logistic regression analysis revealed that a lower habitual intake of EPA+DHA was significantly associated with poor functional mobility in men but not in women (OR (95%CI) per 1 SD increase of EPA+DHA intake; 0.55 (0.33-0.91), 0.88 (0.59-1.32), men and women respectively). Conclusions: Habitual intake of MOPUFA was associated with functional mobility in community-dwelling oldest old men.

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Available from: Michio Hashimoto, Aug 05, 2014
    • "A potential role of n-3 polyunsaturated fatty acids (PUFA) in preventing age-related physical decline could partly be explained by their anti-inflammatory properties and their ability to increase muscle protein synthesis [6] [7], while n-6 PUFAs and their derivatives exhibit inflammatory properties [8]. So far, few studies have explored the association between dietary intake of n-3 PUFA and physical performance in older adults and have provided inconsistent results [9] [10]. A reason for such discrepancies may be the recall bias inherent to available dietary assessment methods, which could lead to subsequent misclassification of the dietary n-3 PUFA exposure [11]. "
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    ABSTRACT: Background & aims: Nutritional factors, such as fatty acids (FA), could modulate physical performance in the elderly. In particular, the opposite properties of long-chain n-3 and n-6 polyunsaturated FAs (LC PUFAs) could impact muscle function. We aimed to assess the cross-sectional association between plasma FAs and gait speed in French elderly community-dwellers. Methods: Elderly participants from the Bordeaux centre of the Three-City Study were included. The proportion of 12 FAs, and gait speed (m/s) were measured concomitantly at enrollment. Low gait speed (LGS) was defined as below the first quartile of gait speed. FA patterns were derived from the 12 individual FAs using principal component analysis. Multivariate logistic regression models were used and odds-ratios (OR) were expressed per one additional standard-deviation unit of each plasma FA or per one additional unit of pattern score. Results: Among 982 participants, 239 (24.3%) had a low gait speed (<0.63 m/s) at baseline. Regarding individually each FA, a higher proportion of eicosapentaenoic acid (EPA) and of docosahexaenoic acid (DHA) were associated with lower odds of LGS (OR = 0.76; 95% CI: 0.63-0.93 and OR = 0.79; 95% CI: 0.67-0.95 respectively). Conversely, a higher arachidonic acid (AA):(EPA + DHA) ratio was associated with higher odds of LGS. Three main FA patterns were identified. A higher score on the FA pattern characterized by higher proportions of LC n-3 PUFAs was associated with lower odds of LGS (OR = 0.78; 95% CI: 0.67-0.90). Conclusions: A FA pattern mainly driven by high plasma concentrations of LC n-3 PUFAs is cross-sectionally associated with higher gait speed in community-dwelling older adults, while a higher AA:(EPA + DHA) ratio is associated with lower gait speed. These findings suggest a potential protective effect of n-3 PUFA on physical performance decline.
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    • "Considering that maintenance of muscle mass is a fundamental determinant of its capacity to generate force, of interest is the potential correlation between PUFAs consumption and muscle strength in the elderly. So far, inconclusive results are available [180, 181]. In particular, in 2009, a cross-sectional study found no correlation between total ω3 or ω6 PUFA intakes and muscle strength in aged Americans [180], whereas, in 2013, the Tokyo Oldest Old Survey on Total Health showed that higher consumption of EPA and DHA is significantly associated with higher functional mobility in men. "
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    ABSTRACT: Age-related bone and muscle loss are major public health problems. Investigational therapies to reduce these losses include anti-inflammatory dietary supplementations, such as polyunsaturated fatty acids (PUFA). Surprisingly, this topic has received little attention in the osteoporosis community. Recent research highlights the role of PUFA in inflammatory regulation of bone remodeling via cellular pathways. Emerging research suggests significant roles for PUFA in reducing bone and muscle loss with aging; however, findings are conflicted for PUFA and fracture risk. Limited studies suggest a relation between higher omega-3 FA and better muscle/bone in older adults. This review highlights new research since 2008 and synthesizes our current understanding of PUFA in relation to bone and muscle. Across study designs, evidence indicates that PUFA has positive effects upon bone. As data are sparse, future clinical trials and prospective studies are important to determine the long term benefits of PUFA supplementation upon bone and muscle outcomes.
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