Article

Moringa Oleifera Leaves Extract Attenuates Male Sexual Dysfunction

American Journal of Neuroscience 01/2012; 3(1):17-24. DOI: 10.3844/amjnsp.2012.17.24

ABSTRACT

Problem statement: At present, the novel agent that is effective, cheap and easy to approach for treating male sexual dysfunction is required due to the current poor therapeutic efficacy. Though Moringa oleifera is reputed for aphrodisiac activity in traditional folklore, no scientific evidence is available. Therefore, we aimed to determine the effect of M.oleifera leaves extract on male sexual behaviors in animal model of sexual dysfunction. Moreover, the possible underlying mechanisms were also investigated. Approach: Male Wistar rats, weighing 200-250 g, had been orally given M.oleifera leaves extract at doses of 10, 50 and 250 mg kg −1 BW once daily at 30 min before the exposure to 12-h immobilization stress for 14 days. They were assessed male sexual behaviors including mounting, intromission and ejaculation numbers and latencies after single administration and every 7 days until the end of experiment. To further investigate the possible mechanisms of action, we also determined serum testosterone level of all rats at the end of experiment together with the determination of suppression effect of the plant extract on MAO B and PDE-5 activities. Results: The results showed that after single administration, rats subjected to M.oleifera extract at dose of 10 mg kg −1 BW significantly enhanced mounting number. When the treatment was prolonged to 7 days rats subjected to the low dose of extract showed the enhanced intromission number whereas rats subjected to high dose of extract showed the enhanced mounting number. Our data also showed no significant change in serum testosterone level. However, the extract could also suppress MAO B and PDE-5 activities. Taken all together, the extract could enhance male sexual desire and performance via the suppression of MAO B and PDE-5 activities. Conclusion: M.oleifera can be the potential sexual enhancer particularly for acute and short term application. However, further researches are necessary.

Download full-text

Full-text

Available from: Sitthichai Iamsaard
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective: To investigate the effect of Anethum graveolens (AG) extracts on the mounting frequency, histology of testis and epididymis, and sperm physiology. Methods: Male rats induced by cold immobilization before treating with vehicle or AG extracts [50, 150, and 450 mg/kg body weight (BW)] via gastric tube for consecutive 1, 7, and 14 d were examined for mounting frequency, testicular phosphorylation level by immunoblotting, sperm concentration, sperm acrosome reaction, and histological structures of testis and epididymis, respectively. Results: AG (50 mg/kg BW) significantly increased the mounting frequency on Days 1 and 7 compared to the control group. Additionally, rat testis treated with 50 mg/kg BW AG showed high levels of phosphorylated proteins as compared with the control group. In histological analyses, AG extract did not affect the sperm concentration, acrosome reaction, and histological structures of testis and epididymis. Conclusions: AG extract enhances the aphrodisiac activity and is not harmful to sperm and male reproductive organs.
    Full-text · Article · Mar 2013 · Journal of Zhejiang University SCIENCE B
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To date, the preventive strategy against dementia is still essential due to the rapid growth of its prevalence and the limited therapeutic efficacy. Based on the crucial role of oxidative stress in age-related dementia and the antioxidant and nootropic activities of Moringa oleifera, the enhancement of spatial memory and neuroprotection of M. oleifera leaves extract in animal model of age-related dementia was determined. The possible underlying mechanism was also investigated. Male Wistar rats, weighing 180-220 g, were orally given M. oleifera leaves extract at doses of 100, 200, and 400 mg/kg at a period of 7 days before and 7 days after the intracerebroventricular administration of AF64A bilaterally. Then, they were assessed memory, neuron density, MDA level, and the activities of SOD, CAT, GSH-Px, and AChE in hippocampus. The results showed that the extract improved spatial memory and neurodegeneration in CA1, CA2, CA3, and dentate gyrus of hippocampus together with the decreased MDA level and AChE activity but increased SOD and CAT activities. Therefore, our data suggest that M. oleifera leaves extract is the potential cognitive enhancer and neuroprotectant. The possible mechanism might occur partly via the decreased oxidative stress and the enhanced cholinergic function. However, further explorations concerning active ingredient(s) are still required.
    Full-text · Article · Dec 2013 · Oxidative Medicine and Cellular Longevity
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Allium sativum is cultivated in the northern part of Ghana and has gained widespread use as chemoprotective, in curing hypertension, impotence and erectile dysfunction. The multipurpose use together with its aphrodisiac activity has resulted in the widespread use of this plant medicine both in meals and as herbal medications. Safety assessment of this plant however is rare. The present study is designed to evaluate the toxic effect of the aqueous extract of Allium sativa on the prostate, heart, liver kidney and haematological parameters after a shorterm administration in male-sprague-dawley rats. The following doses were used in different groups of male Sprague-Dawley Rats: 5000, 3000 and 1000 mg kg-1. The following parameters were monitored: Clinical Chemistry, Gross and Histopathology (Heart, kidney, liver and prostate). No death was recorded at the highest dose of 5000 mg kg-1. ASE reduced levels of urea and creatinine but increased levels of liver enzymes ALT, AST, ALP and bilirubin levels as compared to the controls. There was a statistically significant increase in WBC count (p<0.005) in all the doses except the median dose. There were no significant change in Red Blood Cell count (RBC) (p<0.003), Haemoglobin (HGB) (p<0.03), Haematocrit (HCT) p<0.0001), Mean Corpuscular Volume (MCV) Other parameters remained relatively unchanged. Gross pathology did not reveal any abnormality. Histopathological analysis showed that the extract did not have any adverse effect on the integrity of these organs. The results were within histopathological limits and did not reveal any abnormality in the examined organs namely: The prostate, kidney, liver and heart which maintained their integrity after the dose administration. Observations were within histopathological limits. ASE is reasonably safe when administered by the oral route within dosages of 1000-5000 mg kg-1 in Sprague dawley rats. This research has provided the safety implications as to the use of this plant.
    Preview · Article · Jan 2014 · American journal of pharmacology and toxicology
Show more