Meningococcal Sepsis Complicating Eculizumab Treatment Despite Prior Vaccination

Renal Transplant Unit, Department of Nephrology, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, the Netherlands.
American Journal of Transplantation (Impact Factor: 5.68). 01/2013; 13(3). DOI: 10.1111/ajt.12032
Source: PubMed
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Available from: Frederike Jose Bemelman, Sep 19, 2014
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    • "e l s e v i e r . c o m / l o c a t e / y c l i m clinical practice, mainly due to the following concerns: a certain, though small, risk of meningococcal infection and sepsis [24] [25], possible immunological complications in the long term, including development of neutralizing antibodies, and the extremely high cost of this treatment. Although approval of eculizumab signified new hope for the aHUS patients, available reports describing pharmacokinetic and pharmacodynamics of this drug remain limited. "
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