No Bugs Bugging You? Emerging Insights into Helicobacter-Negative Gastritis

Miraca Life Sciences Research Institute, Miraca Life Sciences, Irving, Texas, USA.
The American Journal of Gastroenterology (Impact Factor: 10.76). 01/2013; 108(1):72-4. DOI: 10.1038/ajg.2012.377
Source: PubMed


Depending on how it is defined, between 3 and 20% of patients who have gastric biopsy specimens are diagnosed with "Helicobacter-negative gastritis." In a paper published in this issue of the Journal, data regarding use of tobacco, alcohol, nonsteroidal anti-inflammatory drugs, and proton pump inhibitors were collected from 41 patients with gastritis in whom no Helicobacters were detected by histology and culture and had negative serology. No significant associations with any of the parameters evaluated were found. Further studies are warranted to elucidate this elusive entity. Additional methods (e.g., the urea breath test and polymerase chain reaction) could be used to exclude Helicobacter infection, and a search for other candidate infectious agents (bacteria and Epstein-Barr virus) should be undertaken in those patients found to be unequivocally uninfected with Helicobacter.

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    ABSTRACT: The American Journal of Gastroenterology is published by Nature Publishing Group (NPG) on behalf of the American College of Gastroenterology (ACG). Ranked the #1 clinical journal covering gastroenterology and hepatology*, The American Journal of Gastroenterology (AJG) provides practical and professional support for clinicians dealing with the gastroenterological disorders seen most often in patients. Published with practicing clinicians in mind, the journal aims to be easily accessible, organizing its content by topic, both online and in print., *2007 Journal Citation Report (Thomson Reuters, 2008)
    No preview · Article · Jul 2013 · The American Journal of Gastroenterology
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