Nanoprisms: Gold Nanoprisms as Optoacoustic Signal Nanoamplifiers for In Vivo Bioimaging of Gastrointestinal Cancers (Small 1/2013)

Department of Bio-Nano Science and Engineering, National Key Laboratory of Micro/Nano, Fabrication Technology, Institute of Micro & Nano Science and Technology, Shanghai JiaoTong University, Shanghai, 200240, China.
Small (Impact Factor: 8.37). 01/2013; 9(1):67. DOI: 10.1002/smll.201370007
Source: PubMed


On page 68, PEGylated gold nanoprisms are designed and prepared by J. M. de la Fuente, D. Cui, and co-workers, with the aim to study the feasibility of using them as a novel contrast agent for the hybrid technique of optoacoustic imaging. The nanoprisms are imaged at different scales using different imaging modalities. They are confirmed as biocompatible, and selected colon cancer HT-29 cells are used as research targets. Shown here is an in silico electron tomographic reconstruction of such gold nanostructures, which show promise for application in biomedical imaging, drug delivery, and photothermal therapy.

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Available from: Chenchen Bao
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    • "anexcellenttoolforinvivoimagingappliedtobiomedicaland pharmaceuticalstudies. Withrespecttooptoacoustics,alladvancesinfluorescent probesaredirectlycompatiblewiththismethodology,since probeswithhighquantumyieldbydefinitionpresenthigh absorptionproperties.Additionally,optoacousticimaging methodsarealsobenefitingfromnewengineeredacousticprobes basedonmetallicnanoparticles(mainlygold)whichexhibithigh absorptionprofiles(Baoetal.,2013;Vonnemannetal.,2014). Finally,averyinterestingandpromisingnewdevelopmentis theuseofCherenkovexcitedluminescenceimaging(CELSI)to improveresolutionandpartiallyavoidtheeffectofabsorption whileexcitingthefluorophores(Zhangetal.,2012,2013b,2015a). "
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