Multiple Myeloma : Recent Progress in Diagnosis and Treatment

ArticleinJournal of Clinical and Experimental Hematopathology 52(3):149-59 · December 2012with15 Reads
DOI: 10.3960/jslrt.52.149 · Source: PubMed


    Multiple myeloma (MM) has been the most intractable hematological disease for many years. Recently, basic and clinical research has advanced remarkably and a new therapeutic strategy has been established. The introduction of high-dose melphalan with autologous stem-cell transplantation and the availability of molecular-targeted novel agents such as immunomodulatory drugs and proteasome inhibitors have dramatically changed the treatment strategies for MM. Achievement of a high response rate resulted in the extension of overall survival, but further research and the development of more multimodality therapeutic approaches is warranted to cure this disease. [J Clin Exp Hematopathol 52(3) : 149-159, 2012].