Diet and Healthy Aging

ArticleinNew England Journal of Medicine 367(26):2550-1 · December 2012with44 Reads
DOI: 10.1056/NEJMcibr1210447 · Source: PubMed
    • "Similarly, the recent DR study in rhesus monkeys performed at the National Institute of Ageing (NIA) revealed that DR did not improve survival outcomes (Mattison et al., 2012; Austad, 2012), in contrast with the findings of the study undertaken by the Wisconsin National Primate Research Center (WNPRC) by Coman and colleagues (Colman et al., 2014Colman et al., , 2009). Several differences exist in terms of experimental design, husbandry and dietary composition between the NIA and WNPRC studies that may help explain the discrepancies in terms the ability of DR to impact on lifespan (Partridge, 2012; Selman, 2014). DR both ameliorates and delays a number of age-associated pathologies in a wide range of organisms, including protection against metabolic dysfunction (e.g. "
    [Show abstract] [Hide abstract] ABSTRACT: Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.
    Full-text · Article · Sep 2016
    • "However, another long-term study conducted by the National Institute of Aging (NIA) in caloricrestricted rhesus monkeys did not show an increase in lifespan (Mattison et al., 2012). This different outcome could be because in the NIA study, the control group food rations had a different dietary composition or because the control group was not fed ad libitum and as a consequence was also subjected to a minor form of caloric restriction (Partridge, 2012). This latter explanation is supported by the fact that the control monkeys in the NIA study weighted substantially less than the national average for body weight in the same age groups (Colman et al., 2014). "
    [Show abstract] [Hide abstract] ABSTRACT: Many diets and nutritional advice are circulating, often based on short- or medium-term clinical trials and primary outcomes, like changes in LDL cholesterol or weight. It remains difficult to assess which dietary interventions can be effective in the long term to reduce the risk of aging-related disease and increase the (healthy) lifespan. At the same time, the scientific discipline that studies the aging process has identified some important nutrient-sensing pathways that modulate the aging process, such as the mTOR and the insulin/insulin-like growth factor signaling pathway. A thorough understanding of the aging process can help assessing the efficacy of dietary interventions aimed at reducing the risk of aging-related diseases. To come to these insights, a synthesis of biogerontological, nutritional, and medical knowledge is needed, which can be framed in a new discipline called 'nutrigerontology'. © 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
    Full-text · Article · Dec 2014
    • "The evidence that CR is capable to extend lifespan in non-human primates was not confirmed in the National Institute of Aging study, which showed that old-onset CR was beneficial on several measures of metabolic health and overall function, and afforded protection against age-associated sarcopenia and neurodegeneration, but did not improve survival outcomes (Mattison et al., 2012; Cava and Fontana, 2013). Besides, the impact on human life span is difficult to study due to the scarce long-term compliance to CR (Roth and Polotsky, 2012; Niccoli and Partridge 2011; Partridge, 2012). Restriction of caloric intake is known to reduce blood sugar and insulin levels and to lower resistance to insulin of peripheral tissues. "
    [Show abstract] [Hide abstract] ABSTRACT: Adult tissue stem cells have the ability to adjust to environmental changes and affect also the proliferation of neighboring cells, with important consequences on tissue maintenance and regeneration. Stem cell renewal and proliferation is strongly regulated during aging of the organism. Caloric restriction is the most powerful anti-aging strategy conserved throughout evolution in the animal kingdom. Recent studies relate the properties of caloric restriction to its ability in reprogramming stem-like cell states and in prolonging the capacity of stem cells to self-renew, proliferate, differentiate, and replace cells in several adult tissues. However this general paradigm presents with exceptions. The scope of this review is to highlight how caloric restriction impacts on diverse stem cell compartments and, by doing so, might differentially delay aging in the tissues of lower and higher organisms.
    Full-text · Article · Nov 2013
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