Article

The genetic basis for interindividual immune response variation to measles vaccine: New understanding and new vaccine approaches

Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
Expert Review of Vaccines (Impact Factor: 4.21). 01/2013; 12(1):57-70. DOI: 10.1586/erv.12.134
Source: PubMed

ABSTRACT

The live-attenuated measles vaccine is effective, but measles outbreaks still occur in vaccinated populations. This warrants elucidation of the determinants of measles vaccine-induced protective immunity. Interindividual variability in markers of measles vaccine-induced immunity, including neutralizing antibody levels, is regulated in part by host genetic factor variations. This review summarizes recent advances in our understanding of measles vaccine immunogenetics relative to the perspective of developing better measles vaccines. Important genetic regulators of measles vaccine-induced immunity, such as HLA class I and HLA class II genotypes, single nucleotide polymorphisms in cytokine/cytokine receptor genes (IL12B, IL12RB1, IL2, IL10) and the cell surface measles virus receptor CD46 gene, have been identified and independently replicated. New technologies present many opportunities for identification of novel genetic signatures and genetic architectures. These findings help explain a variety of immune response-related phenotypes and promote a new paradigm of 'vaccinomics' for novel vaccine development.

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    • "Papillomavirus and smallpox vaccines induce similar inflammatory and IFN signatures [39,40], as well as cytokine production and genes associated with cytotoxicity and cell cycle pathways. Recent advances in measles vaccine immunogenetics are covered in detail by Haralambieva et al. [41]. Not all individuals respond equally well to the same vaccine. "
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