Familial leiomyomatosis cutis affecting nine family members in two successive generations including four cases of Reed's syndrome

ArticleinIndian journal of dermatology, venereology and leprology 79(1):83-7 · January 2013with8 Reads
Impact Factor: 1.39 · DOI: 10.4103/0378-6323.104674 · Source: PubMed


    Reed's syndrome or familial leiomyomatosis cutis et uteri is an autosomal dominant disorder, characterized by multiple cutaneous and uterine leiomyomas. We report here a case of a 53-year-old woman who presented to us with multiple painful nodules over different parts of her body. Based on the histopathological examination, imaging, and past medical records, a diagnosis of Reed's syndrome was made. Three of her sisters had similar disease. Subsequently, it was found that a total of nine members of their family in two successive generations were affected with cutaneous leiomyomas. The present case series has been reported for its interesting clinical presentations and rarity.