Changes in Incidence of Anogenital Warts Diagnoses After the Introduction of Human Papillomavirus Vaccination in Germany-An Ecologic Study

and ¶Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany.
Sexually transmitted diseases (Impact Factor: 2.84). 01/2013; 40(1):28-31. DOI: 10.1097/OLQ.0b013e3182756efd
Source: PubMed


In a large health insurance database in Germany, incidence of anogenital warts among 15- to 19-year-old females decreased from 316/100,000 person-years in 2007 to 242 in 2008 (23% reduction, P = 0.0001). The decrease started between the first and second quarter of 2007 (human papillomavirus vaccination was introduced in March 2007).

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    • "Emerging data from other countries further strengthen evidence of direct and indirect impact of the quadrivalent HPV vaccine. These include countries with high vaccination coverage (Denmark [16] and Sweden [17]), but also countries with lower coverage such as the United States [18] [19], Germany [20], and New Zealand [21]. In the United States, an ecologic analysis of private health insurance claims data found a 38% decrease in genital warts claims in 15-to 19-year-old females, from 2.9 to 1.8 per 1,000 person-years, and a smaller decrease in females aged 21e30 years, but no change in those older than 30 years [18]. "
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