Evaluation of Anti-Diarrhoeal Property and Acute Toxicity of Triphala Mashi , an Ayurvedic Formulation

Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Maharashtra, India.
Journal of Herbal Pharmacotherapy 02/2007; 7(3-4):203-12. DOI: 10.1080/15228940802152869
Source: PubMed


The anti-diarrhoeal effect of aqueous and alcoholic extracts of Triphala and Triphala Mashi were studied employing castor oil-induced-diarrhoeal model in rats. The gastrointestinal transit rate was expressed as the percentage of the longest distance travelled by the charcoal divided by the total length of the small intestine. All the extracts, at various doses 200, 400 and 800 mg/kg displayed remarkable anti-diarrhoeal activity as evidenced by a significant increase in first defecation time, cumulative fecal weight and intestinal transit time. Aqueous and alcoholic extracts of Triphala and Triphala Mashi were considered safe up to a dose of 1750 mg/kg when evaluated for acute oral toxicity in accordance with the OECD (Organization for Economic Cooperation and Development) guidelines. In conclusion, the remarkable anti-diarrhoeal effect of Triphala and Triphala Mashi extracts against castor oil-induced diarrhoea suggest its potential for application in a wide range of diarrhoeal states.

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Available from: Randhir Singh Dahiya, Jan 01, 2014
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    • "The intra peritoneal LD50 dose of Itrifal Saghir was found to be 280 mg/kg [36]. Another study showed the aqueous and alcoholic extracts of Itrifal Saghir up to a dose of 1750 mg/kg were considered safe when evaluated for acute oral toxicity performed in accordance with the Organization for Economic Cooperation and Development guidelines [37]. Indeed no drug-induced mortality has been reported [36]. "
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    ABSTRACT: Herbal combination of Itrifal Saghir (triphala) has been widely used in traditional medicine. And brings health benefits such as antioxidant effect and scavenger of hydroxyl radicals and nitric oxide radicals activity and substantiated in traditional medicine a anti-obesity. In this study we aimed to assess the efficacy of this herbal medicinal on reduction of weight and body mass index (BMI) of simple obese subjects in comparison with placebo. Obese subjects aged between 16 and 60 years were selected for 12-week, double-blind, randomized, placebo-controlled trial using a parallel design. Subjects were randomly assigned to take 5 grams of either the Itrifal Saghir (n = 31) or placebo (n = 31), 2 times daily for 12 weeks. Measures of body weight, BMI, waist circumference (WC), hip circumference (HC), were assessed at baseline and once every four weeks during the 12 week treatment period. The safety was evaluated by means of measuring the liver and kidney function. Homeostasis model of insulin resistance (HOMA-IR) was calculated as [fasting insulin (μU/mL) × fasting glucose (mmol/L)/22.5]. Compared to placebo group, in treatment group the mean difference of effective weight loss was 4.82Kg (CI95% 3.52 - 6.11, ρ < 0.001), the mean of decrease in waist circumference was 4.01 cm (CI 95% 2.13 - 5.90, ρ < 0.001), and the mean decrease in hip circumference was 3. 21 cm (CI 95% 1.96 - 4.45, ρ < 0.001) in treated subjects. No adverse effects or significant changes in liver and kidney function tests were observed in both placebo and treated groups. Itrifal Saghir appears to produce a positive effect on weight loss in obese subjects.
    Full-text · Article · Sep 2012 · DARU-JOURNAL OF FACULTY OF PHARMACY

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    ABSTRACT: Triphala is one of the most important and potent Rasayana drug used in Indian System of Medicine. Triphala is a tridoshic rasyana having a balancing and rejuvenating effect on the three constitutional elements that constitute the human life. Triphala is rich in antioxidants, possess antibacterial, anti-viral, anti-cancer property. Triphala is also known to cure cataract and effective in treatment of Acquired immune deficiency syndrome (AIDS). Triphala is rich in many polyphenols, Vitamin C, and flavonoids. This review paper focuses on the phytochemical and therapeutic effect of triphala.
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