Structure and biological functions of IL-31 and IL-31 receptors

Division of Medical Cell Biology, College of Life Sciences, Sichuan University, Chengdu, PR China.
Cytokine & growth factor reviews (Impact Factor: 5.36). 11/2008; 19(5-6):347-56. DOI: 10.1016/j.cytogfr.2008.08.003
Source: PubMed


Interleukin-31, produced mainly by activated CD4(+) T cells, is a newly discovered member of the gp130/IL-6 cytokine family. Unlike all the other family members, IL-31 does not engage gp130. Its receptor heterodimer consists of a unique gp130-like receptor chain IL-31RA, and the receptor subunit OSMRbeta that is shared with another family member oncostatin M (OSM). Binding of IL-31 to its receptor activates Jak/STAT, PI3K/AKT and MAPK pathways. IL-31 acts on a broad range of immune- and non-immune cells and therefore possesses potential pleiotropic physiological functions, including regulating hematopoiesis and immune response, causing inflammatory bowel disease, airway hypersensitivity and dermatitis. This review summarizes the recent findings on the biological characterization and physiological roles of IL-31 and its receptors.

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    • "Recent studies have shown that IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRß). IL-31 might be involved in controlling keratinocyte differentiation and proliferation and also has a number of effects that point to a role in the regulation of immune responses in skin [8] [11]. "
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    ABSTRACT: Primary localized cutaneous amyloidosis (PLCA) is a chronic skin disorder, caused by amyloid material deposition in the upper dermis. Autosomal dominant PLCA has been mapped earlier to pathogenic missense mutations in the OSMR gene, which encodes the oncostatin M receptor ß subunit (OSMRß). OSMRß is interleukin-6 family cytokine receptors and possesses two ligands, oncostatin M and interleukin-31, which both have biologic roles in inflammation and keratinocyte cell proliferation, differentiation, and apoptosis. Here, we identified a new OSMR mutation in a Kurdish family for the first time. Blood samples were taken from all the affected individuals in the family. DNA extraction was performed using salting out technique. Primers were designed for intron flanking individual exons of OSMR gene which were subjected to direct sequencing after PCR amplification for each sample. Sequencing showed a C/T substitution at position 613 in the proband. This mutation results in an L613S (leucine 613 to serine) amino acid change. The identified mutation was observed in all affected family members but not in 100 ethnically matched healthy controls. Elucidating the molecular basis of familial PLCA provides new insight into mechanisms of itch in human skin and may lead to new therapeutic targets for pruritus.
    Full-text · Article · Jun 2014 · BioMed Research International
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    • "Several studies have reported associations with SCS/CM with genetic markers on chromosome 20 (Sodeland et al., 2011; Meredith et al., 2012; Sahana et al., 2013) with many of them overlapping or nearby the regions detected in this study. Nevertheless, a number of possible candidate genes have been identified including the IL31Rα gene which acts as part of a receptor complex for the IL-31 cytokine in the activation of signaling pathways including the JAK-STAT and MAPK pathways which can initiate a wide range of immunological processes (Zhang et al., 2008; Cornelissen et al., 2012). The detection of a QTL region in close proximity to a number of genes of the complement system also looks promising given the importance of the complement system in both host innate and adaptive immunity. "
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    Full-text · Article · Nov 2013 · Frontiers in Genetics
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    • "Among the top 25 genes obtained by integrating CN gains with somatic mutations were known DLBCL-associated oncogenes such as PIM1 [26], CARD11 [27], MYC, EZH2 [28], and BCL2 [29]. In addition, the analysis identified KLHL6 (a target of CN gains in 23% of cases and mutations in 8%), a gene involved in BCR signaling and germinal center formation in mice [30], IL31 (CN gains in 18% of cases and mutations in 3%), a gene involved in the activation of JAK/STAT, PI3K/AKT and MAPK signaling [31], and LRP1 (gained in 24% of cases and mutated in 3%), a gene promoting cancer cell invasion [32]. "
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    Full-text · Article · Mar 2013 · BMC Systems Biology
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