Deodorant Use and Breast Cancer Risk

The Whiteley-Martin Research Centre, Discipline of Surgery
Epidemiology (Cambridge, Mass.) (Impact Factor: 6.2). 01/2013; 24(1):172. DOI: 10.1097/EDE.0b013e3182781684
Source: PubMed
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    ABSTRACT: The human breast is likely exposed to Al (aluminium) from many sources including diet and personal care products. Underarm applications of aluminium salt-based antiperspirant provide a possible long-term source of exposure, especially after underarm applications to shaved and abraded skin. Al research in breast fluids likely reflects the intraductal microenvironment. We found increased levels of aluminium in noninvasively collected nipple aspirate fluids (NAF) from 19 breast cancer patients compared with 16 healthy control subjects (268 vs 131μg/l, respectively; p<0.0001). In the same NAF samples we found significantly increased levels of protein oxidative carbonyls in cancer patients compared to healthy women (2.35 vs 0.41nmol/mg prot, respectively; p<0.0001). Aluminium content and carbonyl levels showed a significant positive linear correlation (r(2) 0.6628, p<0.0001). In cancer NAF samples (containing higher amounts of aluminium salts) we also found a significantly increased levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-12 p70, and TNF-α) and chemoattractant CC and CXC chemokines (IL-8, MIP-1α and MCP-1). In 12 invasive cancer NAF samples we found a significant positive linear correlation among aluminium, carbonyls and pro-inflammatory IL-6 cytokine (Y=64.79x-39.63, r(2) 0.8192, p<0.0005), as well as pro-inflammatory monocyte chemoattractant MCP-1 cytokine (Y=2026x-866, r(2) 0.9495, p<0.0001). In addition to emerging evidence, our results support the possible involvement of aluminium ions in oxidative and inflammatory status perturbations of breast cancer microenvironment, suggesting aluminium accumulation in breast microenvironment as a possible risk factor for oxidative/inflammatory phenotype of breast cells.
    Full-text · Article · Jul 2013 · Journal of inorganic biochemistry
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    ABSTRACT: Breast Cancer (BC) is a life-changing event. Compared to other malignancies in women, BC has received considerably more public attention. Despite improved neoadjuvant, adjuvant, and palliative treatment strategies for each characteristic molecular BC subtype, recommendations for evidence-based preventive strategies for BC treatment are not given equivalent attention. This may be partly due to the fact that high-quality long-term prevention studies are still difficult to carry out and are thus underrepresented in international studies. The aim of this review is to discuss the most relevant lifestyle factors associated with BC and to identify and discuss the evidence supporting practical prevention strategies that can be used in everyday clinical practice.
    No preview · Article · Dec 2014 · Breast Care
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    ABSTRACT: Today, underarm and antiperspirant deodorants are extensively consumed cosmetic products in order to prevent sweating. Increasing use of these products is revived the claims of increasing of breast cancer risk. While discussing these claims, drawn attention at society, in the popular press and on the Internet, it has begun to discuss in the scientific literature at the same time. There are academic studies which are shown the relation between underarm cosmetic products and breast cancer as well as the opposites. In this article, literature about whether there is relationship between underarm cosmetic products and breast cancer is reviewed and obtained findings are explained. ÖzetGünümüzde koltuk altı ve antiperspirant deodorantlar terlemeyi önlemek amacıyla yaygın olarak kullanılan kozmetik ürünlerdir. Bu ürünlerin kullanımının artması, özellikle meme kanseri riskini arttırdığı iddialarını gündeme getirmiştir. Toplumun ilgisini de çeken bu iddialar popüler basın ve internet üzerinde tartışılırken, aynı zamanda bilimsel literatürde de tartışılmaya başlamıştır. Literatürde koltuk altı kozmetik ürünlerle meme kanseri arasında ilişki olduğunu belirten çalışmaların yanı sıra ilişki olmadığını gösteren çalışmalarda yer almaktadır. Bu makalede, koltuk altı kozmetik ürünlerle meme kanseri arasında ilişki olup olmadığına ilişkin literatür taranmış ve elde edilen bulgular açıklanmıştır.
    Full-text · Article · Jan 2016