Article

Evaluation of the Association between Maternal Smoking, Childhood Obesity, and Metabolic Disorders: A National Toxicology Program Workshop Review

and Division of National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
Environmental Health Perspectives (Impact Factor: 7.98). 12/2012; 121(2). DOI: 10.1289/ehp.1205404
Source: PubMed

ABSTRACT

Background: An emerging literature suggests that environmental chemicals may play a role in the development of childhood obesity and metabolic disorders, especially when exposure occurs early in life.
Objective: Here we assess the association between these health outcomes and exposure to maternal smoking during pregnancy as part of a broader effort to develop a research agenda to better understand the role of environmental chemicals as potential risk factors for obesity and metabolic disorders.
Methods: PubMed was searched up to 8 March 2012 for epidemiological and experimental animal studies related to maternal smoking or nicotine exposure during pregnancy and childhood obesity or metabolic disorders at any age. A total of 101 studies—83 in humans and 18 in animals—were identified as the primary literature.
Discussion: Current epidemiological data support a positive association between maternal smoking and increased risk of obesity or overweight in offspring. The data strongly suggest a causal relation, although the possibility that the association is attributable to unmeasured residual confounding cannot be completely ruled out. This conclusion is supported by findings from laboratory animals exposed to nicotine during development. The existing literature on human exposures does not support an association between maternal smoking during pregnancy and type 1 diabetes in offspring. Too few human studies have assessed outcomes related to type 2 diabetes or metabolic syndrome to reach conclusions based on patterns of findings. There may be a number of mechanistic pathways important for the development of aberrant metabolic outcomes following perinatal exposure to cigarette smoke, which remain largely unexplored.
Conclusions: From a toxicological perspective, the linkages between maternal smoking during pregnancy and childhood overweight/obesity provide proof-of-concept of how early-life exposure to an environmental toxicant can be a risk factor for childhood obesity.

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Available from: Edward D Levin, May 18, 2015
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    • "Nicotine also accumulates in breast milk, placental tissue, amniotic fluid, and fetal blood (Luck & Nau 1984, Dahlstrom et al. 1990), leading to significant fetal and neonatal exposure. Research in animal models have clearly demonstrated that fetal and neonatal exposure to nicotine results in a wide range of short-and long-term health consequences for the offspring, including deficits in postnatal reproductive function (Bruin et al. 2010, Behl et al. 2013). Adverse effects of nicotine exposure during pregnancy on reproductive outcomes Pregnancy There is no doubt that maternal smoking is associated with numerous adverse pregnancy outcomes, including an increased risk of spontaneous abortion, preterm birth, stillbirth, fetal growth restriction, and low birthweight (U.S. "
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