Preventing Lethal Hospital Outbreaks of Antibiotic-Resistant Bacteria

ArticleinNew England Journal of Medicine 367(23):2168-2170 · December 2012with10 Reads
Impact Factor: 55.87 · DOI: 10.1056/NEJMp1212370 · Source: PubMed

The threat of infections due to multidrug-resistant organisms is increasing, and multidrug-resistant gram-negative rods are the most menacing such organisms. Reliable adherence to basic practices is the key to interrupting transmission in our hospitals.

    • "Dihydropyran is one of the most commonly encountered heterocycles , which forms the important component of pharmacophores for a number of compounds having medicinal signiicance including anticancer, antiviral, antibacterial, antioxidant , anti-HIV, antihyperglycemic and anti-dyslipidemic activities [1][2][3][4][5]. Recognizing the considerable importance of the compounds, research focused on the synthesis of new dihydropyran derivatives. "
    [Show abstract] [Hide abstract] ABSTRACT: C22H18N2O3, triclinic, P1̅ (no. 2), a = 8.5476(10) Å, b = 8.7361(10) Å, c = 13.0076(12) Å, α = 80.085(8)°, β = 79.20(1)°, γ = 81.66(1)°, V = 933.43(18) Å3, Z = 2, Rgt(F) = 0.0582, wRref(F2) = 0.1886, T = 293 K.
    Full-text · Article · Jan 2016 · Zeitschrift für Kristallographie. New crystal structures
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    • "A clearing zone of 9 mm for Gram-positive and gram-negative bacteria and 10 mm for fungi or greater was used as the criterion for designating significant antibacterial and antifungal activity (Faizi et al., 2003) [14].The in vitro MIC results were classified as per Pessini et al. (2003)[15]. The extracts that displayed MIC lower than 100 µg/ml, the antimicrobial activity was considered very high; from 100-500 µg/m l, high, 500-1000 µg/m l, moderate; 1000-4000 µg/ml, low and anything above this, the extracts were considered inactive for both bacteria and fungi1617181920. "
    [Show abstract] [Hide abstract] ABSTRACT: Abstract Multi drug resistance of pathogens to drugs has become a universal problem. The aim the study was to investigate if plants’ natural products could offer alternative solutions to the problems. Roots of the plant were collected from Keiyo District; air dried in the shade then ground into fine powder and extracted with methanol, analytical grade, which eventually evaporated using a rotor evaporator. Known amount of the resultant material was measured and dissolved using 1 ml of dimethyl sulphoxide and topped with deionized water to form a known concentration. Serial dilutions of the drug were further made. Disc diffusion methods was used in the microbial studies with registered microorganisms at the National Public Health Laboratory, Nairobi. There were indications that the plant’s extracts possessed reasonable antimicrobial activities. The other portion of the extracts was subjected to wet bench studies which revealed the presence of several classes of compounds that are known to have curative properties. It was evident that the local inhabitants are justified to use the plant in the management of various that inflict them and it was recommended that the plants extracts cytotoxicity in higher animals be evaluated so as to justify its continued used in folklore medicine. It was also recommended that the compounds in the plant be further elucidated to assess their potential as sources of new compounds that could be used by the pharmaceutical concerns in new drugs development.
    Full-text · Article · Sep 2015
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    • "Staphylococcus aureus (S. aureus) is a main pathogen responsible for a number of diseases from serious hospital infections and community acquired infections (Sandora and Goldmann 2012; Frisina et al. 2013). There is still no specific and selective antibacterial agents to kill Methicillin-resistant S. aureus (MRSA), which is the major cause of high death rate of patients in hospital because of its emergence, spread and rapid evolution (Gordon and Lowy 2008; Malani 2013). "
    [Show abstract] [Hide abstract] ABSTRACT: A series of bisoumarin (1-4) and dihydropyran (5-8) derivatives were successfully synthesized as new antibacterial agents. The molecular structures of three representative compounds 1, 5 and 7 were confirmed by single crystal X-ray diffraction study. Among these compounds tested toward Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC), compounds 1 and 2 displayed the most potent antibacterial activity. Additionally, the HB energy in biscoumarins 1-4 was calculated by density functional theory (DFT) [B3LYP/6-31G*] method.
    Full-text · Article · Jun 2015 · Archives of Pharmacal Research
    Jing Li Jing Li Xiao-Yan Xue Xiao-Yan Xue Xia Li Xia Li +7 more authors... Zheng Hou Zheng Hou
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