The role of frozen sections in gynaecological oncology: Survey of practice in the United Kingdom

Department of Histopathology, Birmingham Womens' NHS Foundation Trust, Birmingham, United Kingdom.
European journal of obstetrics, gynecology, and reproductive biology (Impact Factor: 1.7). 11/2012; 166(2). DOI: 10.1016/j.ejogrb.2012.10.024
Source: PubMed


To assess the use of frozen section diagnosis in gynaecological oncology in the United Kingdom.

Study design:
A questionnaire was circulated electronically to gynaecological pathologists and surgeons. The results were collated and compared with the available literature on this subject.

Our survey showed that the use of frozen sections varies with the resource setting and the preferences and practices of the practitioners. Frozen sections are most often used in diagnosis of ovarian/pelvic masses and assessment of lymph nodes in cervical carcinoma.

Frozen section diagnosis is of value in certain areas of gynaecological oncology, while it is of limited or no value in others. Each multidisciplinary team should develop their own local protocols for intraoperative frozen section examination and support developing expertise in frozen section diagnosis in the adopted areas of the practice.

30 Reads
  • [Show abstract] [Hide abstract]
    ABSTRACT: Frozen sections are a valuable resource when utilised properly. This review aims to raise awareness of the strengths and limitations of its use in gynaecological surgery. This is a review of literature combined with experience and survey of the practice in the United Kingdom. Frozen sections are a valuable adjunct to diagnosis and management in gynaecological surgery, when requested appropriately, handled by a pathologist who is aware of the clinicopathologic setting and accepted by a surgeon who is acquainted with the limitations of the procedure.
    No preview · Article · Jan 2014 · Archives of Gynecology
  • [Show abstract] [Hide abstract]
    ABSTRACT: Purpose: To compare the diagnostic accuracy of the neutrophil/lymphocyte ratio (NLR) with the platelet/lymphocyte ratio (PLR) in predicting malignancy of pelvic masses which are pre-operatively malignant suspicious. Materials and methods: In this retrospective study we evaluated the clinical features of patients with ovarian masses which had pre-operatively been considered suspicious for malignancy. The patients whose intraoperative frozen sections were malign were classified as the study group, while those who had benign masses were the control group. Data recorded were age of the patient, diameter of the mass, pre-operative serum Ca 125 levels, platelet count, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio. Results: There was statistically significantly difference between the groups in terms of age, diameter of the mass, serum Ca 125 levels, platelet number and platelet/lymphocyte ratio. Mean neutrophil/lymphocyte ratios showed no difference between the groups. ROC curve analysis showed that age, serum Ca 125 levels, platelet number and PLR were discriminative markers in predicting malignancy in adnexal masses. Conclusions: According to the current study, serum Ca 125 levels, pre-operative platelet number and PLR may be good prognostic factors, while NLR is an ineffective marker in predicting the malignant characteristics of a pelvic mass.
    No preview · Article · Aug 2014 · Asian Pacific journal of cancer prevention: APJCP