Neuroligins help dendrites keep up with the Joneses
Center for Neuroscience, University of California Davis, Davis, California, USA. Nature Neuroscience
(Impact Factor: 16.1).
11/2012; 15(12):1609-11. DOI: 10.1038/nn.3271
Available from: Ruoqi Gao
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ABSTRACT: Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with complex genetic architectures but overlapping behavioral phenotypes, which suggests common pathway perturbations. Multiple lines of evidence implicate imbalances in excitatory and inhibitory activity (E/I imbalance) as a shared pathophysiological mechanism. Thus, understanding the molecular underpinnings of E/I imbalance may provide essential insight into the etiology of these disorders and may uncover novel targets for future drug discovery. Here, we review key genetic, physiological, neuropathological, functional, and pathway studies that suggest alterations to excitatory/inhibitory circuits are keys to ASD and SCZ pathogenesis.
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