High fructose corn syrup and diabetes prevalence: A global perspective

a Department of Preventive Medicine , University of Southern California , Los Angeles , CA , USA.
Global Public Health (Impact Factor: 0.92). 11/2012; 8(1). DOI: 10.1080/17441692.2012.736257
Source: PubMed


Abstract The overall aim of this study was to evaluate, from a global and ecological perspective, the relationships between availability of high fructose corn syrup (HFCS) and prevalence of type 2 diabetes. Using published resources, country-level estimates (n=43 countries) were obtained for: total sugar, HFCS and total calorie availability, obesity, two separate prevalence estimates for diabetes, prevalence estimate for impaired glucose tolerance and fasting plasma glucose. Pearson's correlations and partial correlations were conducted in order to explore associations between dietary availability and obesity and diabetes prevalence. Diabetes prevalence was 20% higher in countries with higher availability of HFCS compared to countries with low availability, and these differences were retained or strengthened after adjusting for country-level estimates of body mass index (BMI), population and gross domestic product (adjusted diabetes prevalence=8.0 vs. 6.7%, p=0.03; fasting plasma glucose=5.34 vs. 5.22 mmol/L, p=0.03) despite similarities in obesity and total sugar and calorie availability. These results suggest that countries with higher availability of HFCS have a higher prevalence of type 2 diabetes independent of obesity.

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Available from: Michael I Goran, Feb 28, 2014
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    • "In addition to HFD, high-sugar diets such as high fructose and sucrose have been more recently recognized as a potential risk of metabolic syndrome and diabetes independent of energy intake (Abdelmalek et al. 2012; Goran et al. 2013). A recent global study revealed that the consumption of high-fructose corn syrup explains a remarkable 20 % increase in T2D incidents [12]. "
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    • "Women with gestational diabetes are at increased risk of development of complications, such as pre-eclampsia during pregnancy and cardiovascular disease later in life (Rich-Edwards et al. 2014). A similar adverse effect of high fructose intake during pregnancy could compromise both the mother and long-term metabolic health of her offspring (Goran et al. 2013). Maternal fructose intake through pregnancy has no effect on fetal weight or postnatal growth, although plasma insulin is modestly reduced (Vickers et al. 2011), but the longer-term responses to fructose feeding during reproduction have only been examined during lactation (Alzamendi et al. 2010). "
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    • "Obesity is an epidemic that is becoming increasingly more prevalent, particularly in Western societies. Fructose, a dietary component, is often implicated in the development and exacerbation of obesity [1] [2] [3] [4] [5] [6]. Much like glucose, fructose is a monosaccharide that is metabolized through the glycolytic pathway [7] [8]. "
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