A Mediator Lost in the War on Cancer

Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: .
Cell (Impact Factor: 32.24). 11/2012; 151(5):927-9. DOI: 10.1016/j.cell.2012.11.003
Source: PubMed


An unexpected role for a Mediator subunit, MED12, in resistance to multiple anticancer agents is revealed by Huang et al. Loss of MED12 confers drug resistance by activating transforming growth factor β (TGF-β) signaling. Inhibition of the TGF-β pathway resensitizes cells to therapeutic drugs, suggesting a new combinatorial cancer treatment.

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