New Directions in the Preoperative Management of Adenocarcinoma of the Rectum

ArticleinCritical reviews in oncogenesis 17(4):393-6 · November 2012with1 Reads
DOI: 10.1615/CritRevOncog.v17.i4.80 · Source: PubMed
  • 41.28 · University of Texas Southwestern Medical Center
Abstract
Pathological complete response is observed in nearly 20% of patients with rectal cancer receiving preoperative chemoradiation. Patients who achieve a pathological complete response have better outcomes compared to patients experiencing no response or partial response. Current strategies have not demonstrated a substantial improvement in augmenting the ratio of responders to partial and nonresponders. The following discussion addresses possible strategies of investigation to increase patients achieving a complete obliteration of rectal tumors following neoadjuvant chemoradio therapies.
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