Spinal cord injury as a trigger to develop periodic leg movements during sleep: An evolutionary perspective

Department of Neurology, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.
Arquivos de neuro-psiquiatria (Impact Factor: 0.84). 11/2012; 70(11):880-4. DOI: 10.1590/S0004-282X2012001100011
Source: PubMed


The primary trigger to periodic limb movement (PLM) during sleep is still unknown. Its association with the restless legs syndrome (RLS) is established in humans and was reported in spinal cord injury (SCI) patients classified by the American Spinal Injury Association (ASIA) as A. Its pathogenesis has not been completely unraveled, though recent advances might enhance our knowledge about those malfunctions. PLM association with central pattern generator (CPG) is one of the possible pathologic mechanisms involved. This article reviewed the advances in PLM and RLS genetics, the evolution of CPG functioning, and the neurotransmitters involved in CPG, PLM and RLS. We have proposed that SCI might be a trigger to develop PLM.

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Available from: Susana Cristina Lerosa Telles, Aug 06, 2014
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    • "Despite the great effort to understand the inhibitory nature of neuronal environment to regenerating fibers, recent results have pointed out neuronal plasticity in the lesioned spinal cord as the major event leading functional recovery in that pathological condition [6] [7] [8] [9] [10]. In fact, studies have identified and characterized molecular signals related to axonal growth and functional target innervation in the lesioned spinal cord. "
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