Lipid mediators in plasma of autism spectrum disorders

Lipids in Health and Disease (Impact Factor: 2.22). 11/2012; 11(1):160. DOI: 10.1186/1476-511X-11-160
Source: PubMed


Inflammation is increasingly recognized as being of both physiological and pathological importance in the immature brain. Cerebellar pathology occurs in autism, as a neurodevelopmental disorder with genetic and environmental origins. The genesis of this disorder is still not understood but inflammation in utero or early in childhood is an environmental risk factor.

Prostaglandin E2 (PGE2), cysteinyl leukotriene as two important lipid mediators together with 8 isoprostane as marker of oxidative stress were measured using ELISA in plasma of 20 male autistic patients compared to 19 age and gender matching control participants.

PGE2, leukotrienes and isoprostanes recorded significantly elevated levels in autistics compared to controls. Role of these measured parameters in inflammation and autoimmunity as two etiological factors in autism were discussed in details.

Receiver Operating Characteristic (ROC) curve analysis shows satisfactory values of area under the curve (AUC) which could reflect the high degree of specificity and sensitivity of the altered PGE2, leukotrienes and isoprostanes as predictive biomarkers in autistic patients from Saudi Arabia.

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Available from: Laila Y Al-Ayadhi, Feb 26, 2014
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    • "The authors identified four main mechanisms that have been increasingly studied during the past decade: immunologic/inflammation, oxidative stress, environmental toxicants, and mitochondrial abnormalities. In addition, there is accumulating research on the lipid, GI systems, microglial activation, and the microbiome, and how these can also contribute to generating biomarkers associated with ASD (45, 46). "
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    • "We consider this result at least partially validated by the recent finding that HDAC1 inhibitors ameliorate social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorder [38]. Similarly, we consider the association between prostaglandin-endoperoxide synthase 1 (PTGS1) and AUTSX2 partially validated by the finding that significantly elevated levels of prostaglandin E2 (PGE2) have been found in autistic patients [39]. "
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