Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study

Department of Bionano Engineering, Hanyang University, Ansan, 426-791, Korea. .
Chemical Communications (Impact Factor: 6.83). 11/2012; 49(23). DOI: 10.1039/c2cc36844g
Source: PubMed


The development of a new class of surfactants for membrane protein manipulation, "GNG amphiphiles", is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).

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Available from: Claus Juul Loland, Jan 07, 2015
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    • "transport system was solved with crystals obtained in MNG-3 by vapor diffusion [74] showing the suitability of this detergent for vapor diffusion crystallization. In addition the structure of an integral membrane pyrophosphatase [75] has been obtained in a related but smaller detergent molecule; glucose neopentylglycol (GNG) [76]. This detergent has a smaller headgroup and a shorter alkyl chain (Fig. 5A). "
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