The Definition and Classification of Dry Eye Disease: Report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007)

The ocular surface (Impact Factor: 3.34). 03/2007; 5(2):75-92. DOI: 10.1016/S1542-0124(12)70081-2


The aim of the DEWs Definition and Classification Subcommittee was to provide a contemporary definition of dry eye disease, supported within a comprehensive classification framework. A new definition of dry eye was developed to reflect current understanding of the disease, and the committee recommended a three-part classification system. The first part is etiopathogenic and illustrates the multiple causes of dry eye. The second is mechanistic and shows how each cause of dry eye may act through a common pathway. It is stressed that any form of dry eye can interact with and exacerbate other forms of dry eye, as part of a vicious circle. Finally, a scheme is presented, based on the severity of the dry eye disease, which is expected to provide a rational basis for therapy. these guidelines are not intended to override the clinical assessment and judgment of an expert clinician in individual cases, but they should prove helpful in the conduct of clinical practice and research.

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    • "Dry eye disease is defined by the Report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop as a multifactorial disease of tears and ocular surface, which results in symptoms of discomfort, visual disturbance, and tear film instability, with potential damage to the ocular surface [1]. Dry eye is a common ocular surface disease that often occurs in the elderly [2]. "
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    ABSTRACT: Purpose. This study aims to evaluate dry eye and ocular surface conditions of myopic teenagers by using questionnaire and clinical examinations. Methods. A total of 496 eyes from 248 myopic teenagers (7–18 years old) were studied. We administered Ocular Surface Disease Index (OSDI) questionnaire, slit-lamp examination, and Keratograph 5M. The patients were divided into 2 groups based on OSDI dry eye standard, and their ocular surfaces and meibomian gland conditions were evaluated. Results. The tear meniscus heights of the dry eye and normal groups were in normal range. Corneal fluorescein scores were significantly higher whereas noninvasive break-up time was dramatically shorter in the dry eye group than in the normal group. All three meibomian gland dysfunction parameters (i.e., meibomian gland orifice scores, meibomian gland secretion scores, and meibomian gland dropout scores) of the dry eye group were significantly higher than those of the normal group ( P < 0.0001 ). Conclusions. The prevalence of dry eye in myopic teenagers is 18.95%. Meibomian gland dysfunction plays an important role in dry eye in myopic teenagers. The Keratograph 5M appears to provide an effective noninvasive method for assessing ocular surface situation of myopic teenagers.
    Full-text · Article · Jan 2016 · Journal of Ophthalmology
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    • "), 눈물샘의 손상뿐만 아니라 안구표면의 염증으로 인한 각결막 상피세포 손상 및 술잔세포의 소실로 눈물막이 불안정해지기도 한다[4,5]. Figure 1. "
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    ABSTRACT: Rheumatic diseases are associated various extra-articular manifestations, such as eye, nerve, pericardium, and pleura. The anterior part of the eye has distinguished anatomic structure resembling synovial joints, thus it is a common site of ocular manifestation in rheumatic disease. These changes include sicca syndrome, peripheral ulcerative keratitis, episcleritis, scleritis, and iritis. Some of these findings may be the clues for the diagnosis of the rheumatic diseases, and some ocular manifestations may represent the activity or prognosis of the rheumatic diseases. These ocular complications may leads to severe visual loss. It is crucial to rule out underlying systemic diagnosis in rheumatic disease associated ocular diseases, and when diagnosed, the coordination of the rheumatologist with the ophthalmologist in the treatment is imperative.
    Full-text · Article · Jan 2016 · Journal of the Korean Medical Association
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    • "Dry eye is defined by the International Dry Eye Workshop as a multifactor disease of the tear film and ocular surface [1] that substantially affects quality of life because of symptoms that include pain and irritation. DED has a negative effect on ocular health and the patient's general health and well-being, as DED often disrupts daily activ- ities [11, 12]. "
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    ABSTRACT: Background: Dry eye is a multifactor disease of the tear film and ocular surface that substantially affects quality of life. Case presentation: Dobesilate administered as eye drops was well tolerated and effective in treating both the objective signs and subjective symptoms of dry eye disease in this 2-week study. Conclusion: To the best of our knowledge, this is the first clinical report of using dobesilate in eye drops. Dobesilate may provide a novel approach to treating drying diseases of the eye.
    Full-text · Article · Dec 2015
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