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Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus

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Conchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguará, is a native and endemic tree from São Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), γ-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5).
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... Kallunki & Pirani, C. gaudichaudianus (A.St.-Hil.) (Mafezoli et al. 2000;Ambrozin et al. 2008;Cortez et al. 2009;Cabral et al. 2012), while acridine alkaloids were identified in C. inopinatus Pirani and C. marginatus (Rizzini) Kallunki & Pirani (Bellete et al. 2012). In regard to phenolic compounds, flavonoids were found in C. heterophyllus (Ambrozin et al. 2008) and coumarins in C. longifolius (Mafezoli et al. 2000). ...
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... Una especie de la familia Rutaceae también mostró la capacidad de inhibir la bioincrustación (Zhou, et al., 2009). La familia Rutaceae tiene alrededor de 140 géneros y 2.000 especies (Cabral, et al., 2012); está compuesta por hierbas, arbustos y pequeños árboles que crecen en todas partes del mundo (Sandjo, et al., 2014;Sichaem, et al., 2014), y se usa en medicina tradicional para el tratamiento de enfermedades (Sandjo, et al., 2014). ¿Cuáles son los principales lugares de origen de las plantas terrestres responsables de los efectos antiincrustantes, y qué partes de las plantas presentan mayor actividad? ...
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... Chemicals may prevent ChE from breaking down ACh, increasing both the level and duration of action of the neurotransmitter ACh (Nigg and Knaak, 2000;Aisa et al., 2012;Cabral et al., 2012). There are natural and synthetic anti-ChE; the natural reversible inhibitors are found in a number of plant toxins, e.g. ...
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... Kusunokinin, haplomyrfolin, and haplomyrfolol were all previously reported in H. vulcanicum, as well as in other IC 50 = 130.2 μM and 26.3 μM against BChE for skimmianine and galantamine, respectively). [29] The moderate inhibition of AChE by skimmianine (67.213 � 0.298 %) as well as dictamnine plus γ-fagarine (52.002 � 0.203 %) was also shown by Cabral et al., [30] as well as Cardoso-Lopez et al. [31] Since presence of these alkaloids was exhibited in Haplophyllum species including H. vulcanicum and H. sahinii screened herein, skimmianine in particular could be considered to contribute ChE inhibitory effect of these species. ...
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