Compared with ICD-10, ICD-11 is closer to treatment guidelines, more rubustly based on biological research evidence. However, not enough data are available in order to reach the target of etiological diagnosis. DSM-5 does not include the idea of depression spectrum; the inclusion in separate chapters of bipolar affective disorder and depressive disorder suggests the differences between the ... [Show full abstract] bipolar spectrum and depression spectrum. ICD-11 eliminates alphanumerical codes (F, followed by 2 or 3 numbers). ICD-11 diagnosis is established through a 4-step decision-tree algorithm. Moreover, descriptive specifiers for most important psychological features or illness evolution specifiers can be attached to the diagnosis.