Quadrivalent Ann Arbor strain live-attenuated influenza vaccine

MedImmune, LLC, Gaithersburg, MD, USA.
Expert Review of Vaccines (Impact Factor: 4.21). 11/2012; 11(11). DOI: 10.1586/erv.12.108
Source: PubMed


Influenza B is responsible for significant morbidity in children and adults worldwide. For more than 25 years, two antigenically distinct lineages of influenza B viruses, B/Yamagata and B/Victoria, have cocirculated globally. Current influenza vaccine formulations are trivalent and contain two influenza subtype A strains (A/H1N1 and A/H3N2) but only one B strain. In a half of recent influenza seasons, the predominant circulating influenza B lineage was different from that contained in trivalent influenza vaccines. A quadrivalent live attenuated influenza vaccine (Q/LAIV) that contains two B strains, one from each lineage, has been developed to help provide broad protection against influenza B. Q/LAIV was recently approved for use in the USA in eligible individuals 2-49 years of age. This review summarizes clinical trial data in support of Q/LAIV.

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    • "tains the live, weakened Ann Arbor influenza strain. This weakened version can replicate efficiently only in limited conditions (Toback et al., 2012). The U.S. FDA (2012a) ap proved it in 2012 for administration to healthy children at least age 2 through adults up to age 49. "
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