Article

Neural population partitioning and a concurrent brain-machine interface for sequential motor function

1] Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA.
Nature Neuroscience (Impact Factor: 16.1). 11/2012; 15(12). DOI: 10.1038/nn.3250
Source: PubMed

ABSTRACT

Although brain-machine interfaces (BMIs) have focused largely on performing single-targeted movements, many natural tasks involve planning a complete sequence of such movements before execution. For these tasks, a BMI that can concurrently decode the full planned sequence before its execution may also consider the higher-level goal of the task to reformulate and perform it more effectively. Using population-wide modeling, we discovered two distinct subpopulations of neurons in the rhesus monkey premotor cortex that allow two planned targets of a sequential movement to be simultaneously held in working memory without degradation. Such marked stability occurred because each subpopulation encoded either only currently held or only newly added target information irrespective of the exact sequence. On the basis of these findings, we developed a BMI that concurrently decodes a full motor sequence in advance of movement and can then accurately execute it as desired.

Download full-text

Full-text

Available from: Ziv Williams, Mar 17, 2014
  • Source
    • "Studies of different types of goal-directed movements, eg. movements to targets, sequential hand movements or movements following prescribed paths indicated that the serial order of submovement 1 , " aspects of movement " (meaning aspects of movement shape and target location) and movement fragments are represented in cortical activity[42,2,3,41,85,40]. Pioneering works by Pollick and Shapiro[68]and Handzel and Flash[35]reported equivalence of the 2/3 power-law model 2 to moving with constant equi-affine velocity and proposed relevance of non-Euclidian geometry, and in particular equi-affine, to the mechanisms of biological movements. "
    [Show description] [Hide description]
    DESCRIPTION: The current version of the manuscript is result of significant revision of the earlier one. It contains novel solutions, some formulations and explanations have been corrected and in many parts of the text improved. The manuscript now contains discussion about performance of the compromised motor control system in the framework of the theory under consideration.
    Full-text · Working Paper · Jan 2016
    • "In this direction, several studies have explored the potential of recording neurons in different cortical areas for BMI applications (Wessberg et al., 2000; Carmena et al., 2003). For example, the premotor cortex can be targeted to separate movement planning from movement execution (Santhanam et al., 2006; Shanechi et al., 2012). Alternatively , the posterior parietal cortex can be targeted to decode higher-level discrete control signals, such as the goals of movements (Musallam et al., 2004), together with continuous control signals related to movements themselves (Mulliken et al., 2008; Hauschild et al., 2012). "
    [Show abstract] [Hide abstract]
    ABSTRACT: The field of invasive brain-machine interfaces (BMIs) is typically associated with neuroprosthetic applications aiming to recover loss of motor function. However, BMIs also represent a powerful tool to address fundamental questions in neuroscience. The observed subjects of BMI experiments can also be considered as indirect observers of their own neurophysiological activity, and the relationship between observed neurons and (artificial) behavior can be genuinely causal rather than indirectly correlative. These two characteristics defy the classical object-observer duality, making BMIs particularly appealing for investigating how information is encoded and decoded by neural circuits in real time, how this coding changes with physiological learning and plasticity, and how it is altered in pathological conditions. Within neuroengineering, BMI is like a tree that opens its branches into many traditional engineering fields, but also extends deep roots into basic neuroscience beyond neuroprosthetics. Copyright © 2015 Elsevier Inc. All rights reserved.
    No preview · Article · Apr 2015 · Neuron
  • Source
    • "In addition, PMd is thought to play an important role in integrating both effectorand spatial goal-related signals for reaching (Cisek et al. 2003; Hoshi and Tanji 2006; Pesaran et al. 2006; Beurze et al. 2010; Gallivan , McLean, Smith, et al. 2011; Gallivan, McLean, Flanagan, et al. 2013). When considering the planning and execution of limb-or hand-related movement sequences, however, the activity of PMd has not often been considered (though see Kettner et al. 1996; Shanechi et al. 2012; Wiestler and Diedrichsen 2013; Kornysheva and Diedrichsen 2014). Thus, a goal of the present study was to fully characterize the activity of PMd in the context of preparing different object-directed action sequences. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Object-manipulation tasks (e.g., drinking from a cup) typically involve sequencing together a series of distinct motor acts (e.g., reaching toward, grasping, lifting, and transporting the cup) in order to accomplish some overarching goal (e.g., quenching thirst). Although several studies in humans have investigated the neural mechanisms supporting the planning of visually guided movements directed toward objects (such as reaching or pointing), only a handful have examined how manipulatory sequences of actions-those that occur after an object has been grasped-are planned and represented in the brain. Here, using event-related functional MRI and pattern decoding methods, we investigated the neural basis of real-object manipulation using a delayed-movement task in which participants first prepared and then executed different object-directed action sequences that varied either in their complexity or final spatial goals. Consistent with previous reports of preparatory brain activity in non-human primates, we found that activity patterns in several frontoparietal areas reliably predicted entire action sequences in advance of movement. Notably, we found that similar sequence-related information could also be decoded from pre-movement signals in object- and body-selective occipitotemporal cortex (OTC). These findings suggest that both frontoparietal and occipitotemporal circuits are engaged in transforming object-related information into complex, goal-directed movements. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
    Full-text · Article · Jan 2015 · Cerebral Cortex
Show more