Earth is a heritage of plants with an abundance of species, many of which are knownamongus, but many of them are still unknown for us. There are many traditional plants whichhavebeen used for medicinal purposes since ancient times, and Nagkesar (Mesua ferrea Linn) isone of them, which is grown in many countries like India, Indochina, Nepal, Thailand, Sri
Lanka and many other countries. It is used to treat diseases like bleeding piles, renal disease, dysentery, fever, and asthma, as well as bacterial and fungal infections. It is knownfor itsmedicinal properties but has also been used as an ornamental plant since ancient times. It contains active phytoconstituents like steroids, coumarins and their derivatives, terpenoids, xanthones and their derivatives, flavonoids and pyranoxanthones, which act as precursors of other ailments. The goal of this study is to summarise the all-pharmacological activities of
Nagkesar as well as some novel uses of Nagkesar. A thorough bibliographic investigationwas launched by examining internationally recognized scientific databases such as Cochranelibrary, PubMed, ScienceDirect, Web of Science, Google scholar, and several data sets fromHerbalist library. We searched several clinical trial databases of the recent past year andprevious systematic reviews from 1980–2022. In this review article, all probablepharmacological effects of the Nagkesar plant, as well as the active components responsiblefor the biological role, are discussed. Nagkesar is important in the treatment of a varietyof ailments. Inflammation, bleeding piles, bronchitis, severe infection, fungal growth, diarrhea, and kidney disease are among conditions that can be treated with the Nagkesar plant.