Prevalence of Vitamin D Insufficiency in Patients With Parkinson Disease and Alzheimer Disease

Department of Neurology, Emory University School of Medicine, 1841 Clifton Road NE, Atlanta, GA 30329, USA.
Archives of neurology (Impact Factor: 7.42). 11/2008; 65(10):1348-52. DOI: 10.1001/archneur.65.10.1348
Source: PubMed


A role for vitamin D deficiency in Parkinson disease (PD) has recently been proposed.
To compare the prevalence of vitamin D deficiency in a research database cohort of patients with PD with the prevalence in age-matched healthy controls and patients with Alzheimer disease (AD).
Survey study and blinded comparison of plasma 25-hydroxyvitamin D (25[OH]D) concentrations of stored samples in a clinical research database at Emory University School of Medicine.
Referral center (PD and AD patients), primary care clinics, and community setting (controls).
Participants were recruited into the study between May 1992 and March 2007. Every fifth consecutively enrolled PD patient was selected from the clinical research database. Unrelated AD (n = 97) and control (n = 99) participants were randomly selected from the database after matching for age, sex, race, APOE genotype, and geographic location.
Prevalence of suboptimal vitamin D and mean 25(OH)D concentrations.
Significantly more patients with PD (55%) had insufficient vitamin D than did controls (36%) or patients with AD (41%; P = .02, chi(2)test). The mean (SD) 25(OH)D concentration in the PD cohort was significantly lower than in the AD and control cohorts (31.9 [13.6] ng/mL vs 34.8 [15.4] ng/mL and 37.0 [14.5] ng/mL, respectively; P = .03).
This report of 25(OH)D concentrations in a predominantly white PD cohort demonstrates a significantly higher prevalence of hypovitaminosis in PD vs both healthy controls and patients with AD. These data support a possible role of vitamin D insufficiency in PD. Further studies are needed to determine the factors contributing to these differences and elucidate the potential role of vitamin D in pathogenesis and clinical course of PD.

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    • "In our previous study, intracranial volume was inversely related with vitamin D (Plózer et al., 2014), the low serum level of which is a correlate or predictor of a wide variety of neurological and psychiatric conditions (Balion et al., 2012; Evatt et al., 2008; Holló et al., 2014). Vitamin D deficiency has been shown to promote cellular proliferation in the nervous system (Ko et al., 2004). "
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    • "The latest meta-analysis of all published observational studies that have measured vitamin D levels in schizophrenic patients confirms a strong association between vitamin D deficiency and schizophrenia (Valipour et al., 2014). Low levels of vitamin D have also been detected in patients with Parkinson's disease (Newmark and Newmark, 2007; Evatt et al., 2008, 2011; Knekt et al., 2010). Outcomes from a randomized clinical trial of vitamin D supplementation in patients with Parkinson disease is eagerly awaited (Suzuki et al., 2013). "
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    • "studies were also reported. Low levels of plasma 25-dihydroxyvitamin D 3 (25-hydroxycholecalciferol, abbreviated as 25(OH)D) were suggested to be associated with mood disorders, dementia, mild cognitive impairment, PD, AD, and cognitive decline [40] [41] [42] [43] [44] [45] [46] [47] [48]. "
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