Current multizone airflow network models assume air momentum effects, contaminant concentrations, and air temperatures are uniformly and homogeneously distributed in a zone of a building. These assumptions can cause errors for zones where air and/or contaminant are not well mixed. A coupled multizone-CFD program has been developed to improve the multizone model by applying a CFD model to those poorly mixed zones and the multizone model to the remaining zones. This paper validates the coupled multizone-CFD program by using experimental data obtained in a four-zone facility with nonuniform distributions of air momentum effects, contaminant concentrations, and air temperatures. The calculated results by the coupled program generally agreed with the experimental data although discrepancies exist in some cases. The coupled multizone-CFD simulations used less computing time than the CFD simulations for the whole flow domain.