ABO Blood Groups and Cardiovascular Diseases

Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA
International journal of vascular medicine 10/2012; 2012(3):641917. DOI: 10.1155/2012/641917
Source: PubMed
ABO blood groups have been associated with various disease phenotypes, particularly cardiovascular diseases. Cardiovascular diseases are the most common causes of death in developed countries and their prevalence rate is rapidly growing in developing countries. There have been substantial historical associations between non-O blood group status and an increase in some cardiovascular disorders. Recent GWASs have identified ABO as a locus for thrombosis, myocardial infarction, and multiple cardiovascular risk biomarkers, refocusing attention on mechanisms and potential for clinical advances. As we highlight in this paper, more recent work is beginning to probe the molecular basis of the disease associations observed in these observational studies. Advances in our understanding of the physiologic importance of various endothelial and platelet-derived circulating glycoproteins are elucidating the mechanisms through which the ABO blood group may determine overall cardiovascular disease risk. The role of blood group antigens in the pathogenesis of various cardiovascular disorders remains a fascinating subject with potential to lead to novel therapeutics and prognostics and to reduce the global burden of cardiovascular diseases.
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    • " The ABO blood groups have a profound influence on haemostasis. [12] They exert major quantitative effects on plasma levels of von Willebrand factor and factor VIII. Increased association of myocardial infarction, ischemic stroke, and venous thromboembolism is seen with blood groups A and AB [13] possibly through functional ABO glycol transferases modulation of thrombosis. A higher risk of cerebral venou"
    [Show abstract] [Hide abstract] ABSTRACT: International Society of Blood Transfusion has recently recognized 33 blood group systems. Apart from ABO and Rhesus system, many other types of antigens have been noticed on the red cell membranes. Blood grouping and cross-matching is one of the few important tests that the anaesthesiologist orders during perioperative period. Hence, a proper understanding of the blood group system, their clinical significance, typing and cross-matching tests, and current perspective are of paramount importance to prevent transfusion-related complications. Nonetheless, the knowledge on blood group system is necessary to approach blood group-linked diseases which are still at the stage of research. This review addresses all these aspects of the blood groups system.
    Full-text · Article · Sep 2014 · Indian journal of anaesthesia
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    • "They have been found that ABO glycotransferase may have broader impact on atherosclerotic than simply throw modulation of thrombosis has linked the ABO locus to circulating levels of soluble intracellular adhesion molecule-1 (sICAM-1) and soluble E- selectin [7]. Furthermore endothelial dysfunction increases risk of type 2 diabetes among women with low level of subclinical incident diabetes [8], so that elevated circulating levels of soluble adhesion molecule used as markers of endothelial dysfunction.Morever their association with type 2 diabetes have been reported [7]. For that reason the present study have been designed to study the association between diabetic, endothelial dysfunction and blood group in Arab Iraqi diabetic women. "
    Full-text · Article · Mar 2014 · Baghdad Science Journal
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    • "The genetic markers employed for the study, namely ABO and STR markers, are used for identification purposes as well as for disease association studies. While disease association has been established for ABO blood groups (He et al., 2012; Trégouët et al., 2009; Zhang et al., 2012), no clear association has yet been found for CODIS STR markers with any disorder or pathological trait. Nevertheless, the authors have found a statistically significant correlation between specific alleles of a locus and some disease (Courts & Madea, 2011). "
    [Show abstract] [Hide abstract] ABSTRACT: Background and aims: Sampling strategies are planned to enhance the homogeneity of a sample, hence to minimize confounding errors. A sampling strategy was developed to minimize the variation within population groups. Karachi, the largest urban agglomeration in Pakistan, was used as a model population. Subjects and methods: Blood groups ABO and Rh factor were determined for 3000 unrelated individuals selected through simple random sampling. Among them five population groups, namely Balochi, Muhajir, Pathan, Punjabi and Sindhi, based on paternal ethnicity were identified. An index was designed to measure the proportion of admixture at parental and grandparental levels. Population models based on index score were proposed. For validation, 175 individuals selected through stratified random sampling were genotyped for the three STR loci CSF1PO, TPOX and TH01. Results: ANOVA showed significant differences across the population groups for blood groups and STR loci distribution. Gene diversity was higher across the sub-population model than in the agglomerated population. At parental level gene diversities are significantly higher across No admixture models than Admixture models. At grandparental level the difference was not significant. Conclusion: A sub-population model with no admixture at parental level was justified for sampling the heterogeneous population of Karachi.
    Full-text · Article · Oct 2013 · Annals of Human Biology
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