ChemInform Abstract: L-Selectride-Mediated Highly Diastereoselective Asymmetric Reductive Aldol Reaction: Access to an Important Subunit for Bioactive Molecules

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Organic Letters (Impact Factor: 6.36). 11/2008; 10(21):4811-4. DOI: 10.1021/ol801971t
Source: PubMed


L-selectride reduction of a chiral or achiral enone followed by reaction of the resulting enolate with optically active alpha-alkoxy aldehydes proceeded with excellent diastereoselectivity. The resulting alpha,alpha-dimethyl-beta-hydroxy ketones are inherent to a variety of biologically active natural products.


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