Dynamic functional and mechanical response of breast tissue to compression

Harvard Medical School, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA.
Optics Express (Impact Factor: 3.49). 10/2008; 16(20):16064-78. DOI: 10.1364/OE.16.016064
Source: PubMed


Physiological tissue dynamics following breast compression offer new contrast mechanisms for evaluating breast health and disease with near infrared spectroscopy. We monitored the total hemoglobin concentration and hemoglobin oxygen saturation in 28 healthy female volunteers subject to repeated fractional mammographic compression. The compression induces a reduction in blood flow, in turn causing a reduction in hemoglobin oxygen saturation. At the same time, a two phase tissue viscoelastic relaxation results in a reduction and redistribution of pressure within the tissue and correspondingly modulates the tissue total hemoglobin concentration and oxygen saturation. We observed a strong correlation between the relaxing pressure and changes in the total hemoglobin concentration bearing evidence of the involvement of different vascular compartments. Consequently, we have developed a model that enables us to disentangle these effects and obtain robust estimates of the tissue oxygen consumption and blood flow. We obtain estimates of 1.9+/-1.3 micromol/100 mL/min for OC and 2.8+/-1.7 mL/100 mL/min for blood flow, consistent with other published values.

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Available from: Juliette Selb, Apr 09, 2015
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    • "Because cells and collagen-rich extracellular matrix (ECM) show strong viscoelastic behavior at physiological loading rates (Guilak et al., 2000; Pryse et al., 2003; Xu et al., 2013; Antoine et al., 2014), viscoelasticity is a factor in almost all biological tissues and organs. Indeed, viscoelastic responses have been studied as metrics of tissue function and health of arteries (Corman et al., 1998), brain parenchyma (Schregel, 2012), liver tissues (Chen et al., 2013), the prostate (Salcudean et al., 2006), skin (Clancy et al., 2010), breasts (Carp et al., 2008), articular cartilage (Edelsten et al., 2010), ligaments (Abramowitch 1751-6161/& 2015 Elsevier Ltd. "
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    • "Results from our previous studies demonstrate the successful integration of digital breast tomosynthesis (DBT) and tomographic optical breast imaging (TOBI), and the advantages provided by a combination of structural and functional images [1] [2]. More recently we have discovered a significant dynamic tissue response to compression, and have shown that these can be exploited to characterize tissue oxygen consumption, blood flow, and mechanical properties [3] [4] [5]. Motivated by these findings, we developed our second generation tomographic optical breast imaging system (TOBI2). "
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