Validation of the Infant-Toddler Checklist as a broadband screener for autism spectrum disorders from 9 to 24 months of age

Florida State University, Tallahassee, FL 32301, USA.
Autism (Impact Factor: 3.5). 10/2008; 12(5):487-511. DOI: 10.1177/1362361308094501
Source: PubMed


There is an urgent requirement for the improvement of early detection of ASDs. This article provides a brief review of research on the accuracy of screeners for children with ASD that have been administered to general pediatric samples and then present results of a population-based study with a broadband screener to detect children with communication delays including children with ASD.

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Available from: Amy Wetherby, Dec 14, 2015
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    • "Chawarska et al. 2013; Elsabbagh et al. 2012; Flanagan et al. 2012; Jones and Klin 2013). Additionally, early screening strategies are being evaluated to enable detection and referral in the first year of life (Bryson et al. 2008) and before the second birthday (Dietz et al. 2006; Reznick et al. 2007; Robins 2008; Wetherby et al. 2008). Further, accumulating studies are documenting that many children can be reliably diagnosed at 18 months of age (Chawarska et al. 2007; Guthrie et al. 2012). "
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    ABSTRACT: Early detection methods for autism spectrum disorder (ASD) in infancy are rapidly advancing, yet the development of interventions for infants under two years with or at-risk for ASD remains limited. In order to guide research and practice, this paper systematically reviewed studies investigating interventions for infants under 24 months with or at-risk for ASD. Nine studies were identified and evaluated for: (a) participants, (b) intervention approach (c) experimental design, and (d) outcomes. Studies that collected parent measures reported positive findings for parent acceptability, satisfaction, and improvement in parent implementation of treatment. Infant gains in social-communicative and developmental skills were observed following intervention in most of the reviewed studies, while comparisons with treatment-as-usual control groups elucidate the need for further research. These studies highlight the feasibility of very early intervention and provide preliminary evidence that intervention for at-risk infants may be beneficial for infants and parents.
    Full-text · Article · Sep 2014 · Journal of Autism and Developmental Disorders
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    • "The CSBS-DP-ITC14 is a general broadband screen that detects a wide range of disorders such as global developmental delay, general language delay, and autism between 6 and 24 months. This 24-item parent-report questionnaire quantifies infant abilities into three subdomains, ie, social and emotional communication, receptive and expressive speech, and symbolic behavior. "
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    ABSTRACT: Studies of children with very low birth weight (VLBW, 1,000-1,500 g) and extremely low birth weight (ELBW, less than 1,000 g) indicate that this population seems to be at increased risk of autism spectrum disorder (ASD). Parents of 101 VLBW and ELBW children (age 2 years, corrected for prematurity) agreed to participate in the study and signed informed consents; however, parents of only 75 children (44 boys, 31 girls) completed the screening questionnaires. The screening battery included the Modified Checklist for Autism in Toddlers (M-CHAT), Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist (CSBS-DP-ITC), and the Infant/Toddler Sensory Profile (ITSP). Children with disabilities were excluded. All children who screened positive on any of the screening tools were subsequently invited for a detailed assessment. Thirty-two children (42.7%) screened positive on at least one of the screening questionnaires. The screening tool with the most positive results was the CSBS-DP-ITC (26 positive screens), followed by the M-CHAT (19 positive screens) and the ITSP (11 positive screens). Of the 32 children who tested positive, 19 participated in the detailed follow-up assessment. A diagnosis of ASD was confirmed in eight of the 19 children. ASD prevalence, calculated from those 19 children and those with negative screening results (43 children), yielded a prevalence of 12.9% in the sample. The difference in frequency of positive screens between the tests was significant (P=0.011). In pair comparisons, ITSP was found to be significantly less positive than CSBS-DP-ITC (P=0.032). No significant differences were found between the M-CHAT and CSBS-DP-ITC or between the M-CHAT and ITSP. The results strongly support the hypothesis of an increased prevalence of autism in children with a birth weight less than 1,500 g.
    Full-text · Article · Feb 2014 · Neuropsychiatric Disease and Treatment
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    • "These items are congruent with a conceptual model reflecting two developmental domains of functioning: social-communication and sensory-regulatory functions. Thus, in comparison to the CSBS-ITC (Wetherby, et al., 2008), that measures primarily red flags for social-communication development, the FYI measures a broader range of behaviors. Reznick et al. (2007) examined the psychometric properties of the FYI and developed a scoring algorithm based on the distribution of item scores in a normative sample of 1,496 infants from North Carolina. "
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    ABSTRACT: The First Year Inventory is a parent-report measure designed to identify 12-month-old infants at risk for autism spectrum disorder. First Year Inventory taps behaviors that indicate risk in the developmental domains of sensory-regulatory and social-communication functioning. This longitudinal study is a follow-up of 699 children at 3 years of age from a community sample whose parents completed the First Year Inventory when their children were 12 months old. Parents of all 699 children completed the Social Responsiveness Scale-Preschool version and the Developmental Concerns Questionnaire to determine age 3 developmental outcomes. In addition, children deemed at risk for autism spectrum disorder based on liberal cut points on the First Year Inventory, Social Responsiveness Scale-Preschool, and/or Developmental Concerns Questionnaire were invited for in-person diagnostic evaluations. We found 9 children who had a confirmed diagnosis of autism spectrum disorder from the sample of 699. Receiver operating characteristic analyses determined that a two-domain cutoff score yielded optimal classification of children: 31% of those meeting algorithm cutoffs had autism spectrum disorder and 85% had a developmental disability or concern by age 3. These results suggest that the First Year Inventory is a promising tool for identifying 12-month-old infants who are at risk for an eventual diagnosis of autism spectrum disorder.
    Full-text · Article · Sep 2013 · Autism
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