Ferritin Concentrations, Metabolic Syndrome, and Type 2 Diabetes in Middle-Aged and Elderly Chinese

Graduate School, Chinese Academy of Sciences, Peping, Beijing, China
Journal of Clinical Endocrinology & Metabolism (Impact Factor: 6.21). 10/2008; 93(12):4690-6. DOI: 10.1210/jc.2008-1159
Source: PubMed


Elevated ferritin concentrations frequently cluster with well-established risk factors of diabetes including obesity, metabolic syndrome, chronic inflammation, and altered circulating adipokines. Few studies, however, have systematically evaluated the effect of these risk factors on ferritin-diabetes association, particularly in Chinese populations.
We aimed to investigate, in a middle-aged and elderly Chinese population, whether elevated ferritin concentrations are associated with higher risk of metabolic syndrome and type 2 diabetes and to what extent the associations were influenced by obesity, inflammation, and adipokines.
We conducted a population-based, cross-sectional survey of 3,289 participants aged 50-70 yr in Beijing and Shanghai in 2005. Fasting plasma ferritin, glucose, insulin, lipid profile, glycohemoglobin, inflammatory markers, adipokines, and dietary profile were measured.
Median ferritin concentrations were 155.7 ng/ml for men and 111.9 ng/ml for women. After multiple adjustment, the odds ratios (ORs) were substantially higher for type 2 diabetes (OR 3.26, 95% confidence interval 2.36-4.51) and metabolic syndrome [OR 2.80 (95% confidence interval 2.24-3.49)] in the highest ferritin quartile compared with those in the lowest quartile. These associations remained significant after further adjustment for dietary factors, body mass index, inflammatory markers, and adipokines.
Elevated circulating ferritin concentrations were associated with higher risk of type 2 diabetes and metabolic syndrome in middle-aged and elderly Chinese independent of obesity, inflammation, adipokines, and other risk factors. Our data support the crucial role of iron overload for metabolic diseases, even in a country with relatively high prevalence of iron deficiency.

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    • "for iron status (Sun et al., 2008), and low grade inflammation , which results in free radical damage to cells and tissues (Arosio and Levi, 2002). Accordingly, recent studies demonstrated that serum ferritin concentrations are correlated with diabetes mellitus (Lee et al., 2011), insulin resistance (Kim et al., 2011), metabolic syndrome (Jehn et al., 2004; Kang et al., 2012), ischemic heart disease (Milman and Kirchhoff, 1999), cardiovascular disease (Sempos et al., 2000), and nonalcoholic fatty liver disease (NAFLD) (Kim et al., 2012a) in healthy men and obese patients (Hsiao et al., 2004). "
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    • "Multiple studies have shown that excess body iron is associated with one or more components of metabolic syndrome (Jehn et al., 2004; Bozzini et al., 2005; Choi et al., 2005; Gonzalez et al., 2006; Sun et al., 2008a). To study the association of iron with metabolic syndrome in normal individuals, a cross-sectional study in 6044 US adults was conducted. "
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